This thesis investigates the drug release from polymeric nanocapsules induced by ultrasonic stimulation. A drug delivery system with stimuli-responsive polymeric nanocapsules was prepared to achieve locally controlled drug release by remote ultrasonic stimulation. This was then compared to the polymeric capsules for spontaneous drug release. Nanocapsules were produced by employing a layer-by-layer technique, encapsulated with Rhodamine 6G dye used in place of anti-restenotic drugs. Ultrasonic stimulation induced dye release was monitored by fluorescence intensity changes in the fluorescence emission spectra taken from the supernatant of the nanocapsule solutions after ultrasonic treatment. Gold nanoparticles were incorporated in the shell of the nanocapsules. The presence of gold nanoparticles significantly enhanced the efficiency of the ultrasonically induced dye release from the nanocapsules and increased the sensitivity of the nanocapsules to ultrasonic stimulation compared to those without gold nanoparticles.
|Date of Award||1 Oct 2015|
- University Of Strathclyde
|Sponsors||University of Strathclyde|
|Supervisor||Wei Yao (Supervisor) & Philip Rowe (Supervisor)|