The direct, selective and efficient functionalization of unactivated C-H bonds, such as those in naturally abundant hydrocarbons, remains one of the most difficult challenges in modern chemistry. However, in the last fifteen years much effort has been expended in developing various biomimetic catalysts that can perform the same functionalizations as those enzymes observed in nature.This review discusses homogeneous monoiron and diiron catalysts, supported by various types of ligands and gives an up to date comparison on their hydroxylation reactivities with hydrocarbon substrates. The key intermediates involved in the reaction mechanisms are highlighted and those crucial steps such as hydrogen atom abstraction and OH rebound are investigated in order to rationalise how a catalystâs design influences its reactivity and also its stability.
|Date of Award||19 Jun 2017|
- University Of Strathclyde
|Supervisor||Colin Gibson (Supervisor) & John Murphy (Supervisor)|