There is an increasing use recreational drugs in recent years. Indeed, this has become more common place and as such, there is a need for new and portable sensors in forensic field illegal drugs. The need for rapid and reliable detection and monitoring in forensic science has resulted in the development of alternative analytical approaches. Electrochemical sensors are strong candidates for detection sensors and currently electrochemical sensors have a wide range application in forensic applications. In this approach a modified GC electrode with nafion was prepared and voltammetry and electrochemiluminescence (ECL) detection were investigated for the detection of methamphetamine. Methamphetamine (MA) was detected by the modified electrode and the system showed a linear working range of lower concentrations of MA compared with that of the unmodified electrode system. The ECL intensity was found to be concentrations over the range of 5 x 10-8 to 2.5 x 10-4 mol/L. LoD for MA is 1.94 x 10-10 mol/L. This approach was applied in different medium such as saliva and human serum to detect MA and its main metabolites. In addition, this approach was shown to detect two of the main metabolites of MA within a variety of biological matrices. Also, iridium and osmium complexes were used to distungish MA and its metabolites in samples. However, the modified electrode systems do not show ECL signal against the analytes.
Date of Award | 23 Sept 2021 |
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Original language | English |
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Awarding Institution | - University Of Strathclyde
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Sponsors | University of Strathclyde |
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Supervisor | Lynn Dennany (Supervisor) & Matthew Baker (Supervisor) |
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