Approaches for rejuvenating the natural product discovery process from Streptomyces

Student thesis: Doctoral Thesis

Abstract

In 1940, a bacterial enzyme was identified which was capable of destroying penicillin (Abraham & Chain, 1940). This discovery actually predated both the awarding of the Nobel Peace Prize in Medicine and Physiology for its discovery and the year it became available over the counter for the first time in the United States by five years (Gaynes, 2017). In short, Antimicrobial Resistance (AMR) is a phenomenon that has long plagued the field of natural product drug discovery. To attempt to overcome come this, it is imperative that the natural product discovery field is shunted forward by the continued advancement of microbial culturing methods and analytical tools (Atanasov et al., 2021). This work contributes towards the rejuvenation of natural product drug discovery by describing new methods for eliciting potentially novel antimicrobial specialised metabolites, as well as outlining metabologenomic methods for analysing the resultant datasets. [See thesis text for references].
Date of Award29 Sept 2023
Original languageEnglish
Awarding Institution
  • University Of Strathclyde
SponsorsUniversity of Strathclyde
SupervisorKatherine Duncan (Supervisor) & Paul Herron (Supervisor)

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