The development of an iridium-catalyzed regio- and stereoselective dimerization process has enabled the formation of (Z)-enyne products. More specifically, low catalyst loadings of an iridium(I) complex, featuring a bulky N-heterocyclic carbene-phosphine ligand combination, has been successfully employed in this selective head-to-head dimerization of terminal alkynes via C-H activation.
- C-H activation
Forsyth, C., Kerr, W. J., & Paterson, L. (2013). Z-selective dimerization of aromatic terminal alkynes catalyzed by an iridium(I) n-heterocyclic carbene-phosphine system. Synlett, 24(5), 587-590. https://doi.org/10.1055/s-0032-1318271