XRT: Extraction of quantitative structural descriptors from solid pharmaceutical products

Research output: Contribution to conferenceSpeech

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Abstract

In this project we demonstrate the use of x-ray tomography for the quantification of structural descriptors from two selected solid pharmaceutical products: single formulated particles and a commercial Ibuprofen capsule. In particular, we demonstrate the application of image processing strategies for noise reduction, image segmentation and the extraction of quantitative structural descriptors. Information on the sample’s solid state properties can be used to evaluate the manufacturing process and allows a prediction of the solid performance for subsequent processing steps or after administration to the patient.
Original languageEnglish
Publication statusPublished - 17 Apr 2018
EventBruker Micro-CT User Meeting - Ghent, Belgium
Duration: 16 Apr 201819 Apr 2018
https://www.bruker.com/events/users-meetings/microct/2018.html

Conference

ConferenceBruker Micro-CT User Meeting
CountryBelgium
CityGhent
Period16/04/1819/04/18
Internet address

Keywords

  • X-ray tomography
  • pharmaceutics
  • pellets
  • capsules
  • characterisation
  • image analysis

Research Output

  • 2 Article
  • 2 Digital or Visual Products
4 Downloads (Pure)
Open Access
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  • 3 Citations (Scopus)
    8 Downloads (Pure)

    Student Theses

    Measurement, optimisation and control of particle properties in pharmaceutical manufacturing processes

    Author: Doerr, F., 18 May 2020

    Supervisor: Florence, A. (Supervisor) & Oswald, I. (Supervisor)

    Student thesis: Doctoral Thesis

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