Wide-bandwidth biological impedance spectroscopy system based on the digital lock-in technique

Nan Li, Wei Wang, Hui Xu, Hongqi Yu, Jietao Diao, David D U Li

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

The spectra of biological impedance can reveal physiological conditions and biological events of biological samples. This paper presents the development of a novel biological impedance spectroscopy system using an improved digital lock-in technique. The hardware of the system mainly consists of a current source, a voltage detector, a clock generator, and a field-programmable gate array (FPGA) device. Digital phase-sensitive detection algorithms including direct digital synthesis, digital multipliers, and digital filters were implemented in the FPGA. Test results show that the proposed spectroscopy has good performance from low frequency to 5 MHz with 1% accuracy. It will be suitable for high-Accuracy biological impedance spectra analysis in either in vitro or in vivo conditions.

LanguageEnglish
Pages476-482
Number of pages7
JournalSpectroscopy Letters
Volume46
Issue number7
Early online date14 Jun 2013
DOIs
Publication statusPublished - 3 Oct 2013

Fingerprint

Field programmable gate arrays (FPGA)
field-programmable gate arrays
Spectroscopy
impedance
bandwidth
Bandwidth
Digital filters
Spectrum analysis
spectroscopy
Clocks
digital filters
multipliers
Detectors
Hardware
clocks
spectrum analysis
hardware
Electric potential
generators
low frequencies

Keywords

  • biological impedance
  • FPGA
  • lock-in amplifier
  • spectroscopy

Cite this

Li, Nan ; Wang, Wei ; Xu, Hui ; Yu, Hongqi ; Diao, Jietao ; Li, David D U. / Wide-bandwidth biological impedance spectroscopy system based on the digital lock-in technique. In: Spectroscopy Letters. 2013 ; Vol. 46, No. 7. pp. 476-482.
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Wide-bandwidth biological impedance spectroscopy system based on the digital lock-in technique. / Li, Nan; Wang, Wei; Xu, Hui; Yu, Hongqi; Diao, Jietao; Li, David D U.

In: Spectroscopy Letters, Vol. 46, No. 7, 03.10.2013, p. 476-482.

Research output: Contribution to journalArticle

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