What does the eye tell the brain?: Development of a system for the large-scale recording of retinal output activity

AM Litke; N Bezayiff; EJ Chichilnisky; W Cunningham; W Dabrowski; AA Grillo; M Grivich; P Grybos; P Hottowy; S Kachiguine; RS Kalmar; K Mathieson; D Petrusca; A Rahman; A Sher

doi:10.1109/TNS.2004.832706

What does the eye tell the brain?: Development of a system for the large-scale recording of retinal output activity

AM Litke, N Bezayiff, EJ Chichilnisky, W Cunningham, W Dabrowski, AA Grillo, M Grivich, P Grybos, P Hottowy, S Kachiguine, RS Kalmar, K Mathieson, D Petrusca, A Rahman, A Sher

Research output: Contribution to journal › Article › peer-review

203 Citations (Scopus)

Abstract

A multielectrode array system has been developed to
study how the retina processes and encodes visual images. This
system can simultaneously record the extracellular electrical activity from hundreds of retinal output neurons as a dynamic visual image is focused on the input neurons. The retinal output signals detected can be correlated with the visual input to study the neural code used by the eye to send information about the visual world to the brain. The system consists of the following components: 1)
a 32 16 rectangular array of 512 planar microelectrodes with a sensitive area of 1.7 mm2 ; the electrode spacing is 60 m and the electrode diameter is 5 m (hexagonal arrays with 519 electrodes are under development); 2) eight 64-channel custom-designed integrated circuits to platinize the electrodes and ac couple the signals; 3) eight 64-channel integrated circuits to amplify, band-pass filter, and analog multiplex the signals; 4) a data acquisition system; and
5) data processing software. This paper will describe the design
of the system, the experimental and data analysis techniques, and
some first results with live retina. The system is based on techniques and expertise acquired in the development of silicon microstrip detectors for high-energy physics experiments.

Original language	English
Pages (from-to)	1434-1440
Number of pages	7
Journal	IEEE Transactions on Nuclear Science
Volume	51
Issue number	4, Part 1
DOIs	https://doi.org/10.1109/TNS.2004.832706
Publication status	Published - 1 Aug 2004

Keywords

analog integrated circuits
visual system
biomedical electrodes
neural networks
image processing

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10.1109/TNS.2004.832706

Cite this

Litke, AM., Bezayiff, N., Chichilnisky, EJ., Cunningham, W., Dabrowski, W., Grillo, AA., Grivich, M., Grybos, P., Hottowy, P., Kachiguine, S., Kalmar, RS., Mathieson, K., Petrusca, D., Rahman, A., & Sher, A. (2004). What does the eye tell the brain?: Development of a system for the large-scale recording of retinal output activity. IEEE Transactions on Nuclear Science, 51(4, Part 1), 1434-1440. https://doi.org/10.1109/TNS.2004.832706

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abstract = "A multielectrode array system has been developed tostudy how the retina processes and encodes visual images. Thissystem can simultaneously record the extracellular electrical activity from hundreds of retinal output neurons as a dynamic visual image is focused on the input neurons. The retinal output signals detected can be correlated with the visual input to study the neural code used by the eye to send information about the visual world to the brain. The system consists of the following components: 1)a 32 16 rectangular array of 512 planar microelectrodes with a sensitive area of 1.7 mm2 ; the electrode spacing is 60 m and the electrode diameter is 5 m (hexagonal arrays with 519 electrodes are under development); 2) eight 64-channel custom-designed integrated circuits to platinize the electrodes and ac couple the signals; 3) eight 64-channel integrated circuits to amplify, band-pass filter, and analog multiplex the signals; 4) a data acquisition system; and5) data processing software. This paper will describe the designof the system, the experimental and data analysis techniques, andsome first results with live retina. The system is based on techniques and expertise acquired in the development of silicon microstrip detectors for high-energy physics experiments.",

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author = "AM Litke and N Bezayiff and EJ Chichilnisky and W Cunningham and W Dabrowski and AA Grillo and M Grivich and P Grybos and P Hottowy and S Kachiguine and RS Kalmar and K Mathieson and D Petrusca and A Rahman and A Sher",

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Litke, AM, Bezayiff, N, Chichilnisky, EJ, Cunningham, W, Dabrowski, W, Grillo, AA, Grivich, M, Grybos, P, Hottowy, P, Kachiguine, S, Kalmar, RS, Mathieson, K, Petrusca, D, Rahman, A & Sher, A 2004, 'What does the eye tell the brain?: Development of a system for the large-scale recording of retinal output activity', IEEE Transactions on Nuclear Science, vol. 51, no. 4, Part 1, pp. 1434-1440. https://doi.org/10.1109/TNS.2004.832706

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AU - Grillo, AA

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AU - Grybos, P

AU - Hottowy, P

AU - Kachiguine, S

AU - Kalmar, RS

AU - Mathieson, K

AU - Petrusca, D

AU - Rahman, A

AU - Sher, A

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KW - visual system

KW - biomedical electrodes

KW - neural networks

KW - image processing

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DO - 10.1109/TNS.2004.832706

M3 - Article

SN - 0018-9499

VL - 51

SP - 1434

EP - 1440

JO - IEEE Transactions on Nuclear Science

JF - IEEE Transactions on Nuclear Science

IS - 4, Part 1

ER -

What does the eye tell the brain?: Development of a system for the large-scale recording of retinal output activity

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Keywords

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Retinal Readout Project

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What does the eye tell the brain?: Development of a system for the large-scale recording of retinal output activity

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Keywords

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Retinal Readout Project

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