Wet milling of mefenamic acid for seed generation: model-driven size reduction for maximizing yield

Introduction•Wet milling overcomes several common issues encountered with dry milling, including:
- Undesired polymorphic and amorphous transformations
- Loss of yield and process control
- Increased energy cost
• The aim of this work is to explore the region of attainable particle sizes based on the performance of a wet milling model, focusing on:
- Development of a mechanistic model from initial small-scale experiments
- Design space exploration to assess the quality attributes and suggest further experimental work with a view to make the model more robust