Weak anion-exchange hypercrosslinked sorbent in on-line solid-phase extraction-liquid chromatography coupling to achieve automated determination with an effective clean-up

N. Fontanals, P.A.G. Cormack, D.C. Sherrington, R.M. Marce, F. Borrull

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

A mixed-mode polymeric sorbent was on-line coupled to liquid chromatography (LC) for the first time and applied it to the selective solid-phase extract a group of pharmaceuticals in complex environmental water samples. The mixed-mode polymeric sorbent is a high-specific surface area hypercrosslinked polymer resin (HXLPP) in the form of monodisperse microspheres further modified with 1,2-ethylenediamine (EDA) moieties. These properties allows its application as a weak anion-exchange (WAX) sorbent in the on-line solid-phase extraction (SPE) coupling. The on-line SPE-LC method developed using the HXLPP-WAX sorbent was successfully applied to percolate a large volume of ultrapure (500 ml), river (250 ml) and effluent sewage (100 ml) water samples. In all the cases, the HXLPP-WAX resin provided near total recoveries of the most acidic compounds studied and clean chromatograms. This is because the ion-exchange interactions enable a washing step to be added to the SPE protocol that removes the compounds with weak acidic, neutral and basic properties from the sample matrix.
LanguageEnglish
Pages2855-2861
Number of pages6
JournalJournal of Chromatography A
Volume1217
Issue number17
DOIs
Publication statusPublished - 2010

Fingerprint

Solid Phase Extraction
Liquid chromatography
Sorbents
Liquid Chromatography
Anions
Ion exchange
ethylenediamine
Anion Exchange Resins
Water
Ion Exchange
Sewage
Microspheres
Rivers
Exchange interactions
Polymers
Washing
Specific surface area
Effluents
Resins
Recovery

Keywords

  • micrometer-sized spherical particles
  • mixed-mode weak anion-exchanger
  • hypercrosslinked resin
  • on-line solid-phase extraction
  • clean-up
  • complex water samples

Cite this

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Weak anion-exchange hypercrosslinked sorbent in on-line solid-phase extraction-liquid chromatography coupling to achieve automated determination with an effective clean-up. / Fontanals, N.; Cormack, P.A.G.; Sherrington, D.C.; Marce, R.M.; Borrull, F.

In: Journal of Chromatography A , Vol. 1217, No. 17, 2010, p. 2855-2861.

Research output: Contribution to journalArticle

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T1 - Weak anion-exchange hypercrosslinked sorbent in on-line solid-phase extraction-liquid chromatography coupling to achieve automated determination with an effective clean-up

AU - Fontanals, N.

AU - Cormack, P.A.G.

AU - Sherrington, D.C.

AU - Marce, R.M.

AU - Borrull, F.

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KW - micrometer-sized spherical particles

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