Research output per year
Research output per year
Stefanie Griesbeck, Zuolun Zhang, Marcus Gutmann, Tessa Lühmann, Robert M. Edkins, Guillaume Clermont, Adina N. Lazar, Martin Haehnel, Katharina Edkins, Antonius Eichhorn, Mireille Blanchard-Desce, Lorenz Meinel, Todd B. Marder
Research output: Contribution to journal › Article › peer-review
Three water-soluble tetracationic quadrupolar chromophores comprising two three-coordinate boron π-acceptor groups bridged by thiophene-containing moieties were synthesised for biological imaging applications. Compound 3 containing the bulkier 5-(3,5-Me2C6H2)-2,2′-(C4H2S)2-5′-(3,5-Me2C6H2) bridge is stable over a long period of time, exhibits a high fluorescence quantum yield and strong one- and two-photon absorption (TPA), and has a TPA cross section of 268 GM at 800 nm in water. Confocal laser scanning fluorescence microscopy studies in live cells indicated localisation of the chromophore at the mitochondria; moreover, cytotoxicity measurements proved biocompatibility. Thus, chromophore 3 has excellent potential for one- and two-photon-excited fluorescence imaging of mitochondrial function in cells.
Original language | English |
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Pages (from-to) | 14701-14706 |
Number of pages | 6 |
Journal | Chemistry - A European Journal |
Volume | 22 |
Issue number | 41 |
Early online date | 15 Sep 2016 |
DOIs | |
Publication status | Published - 4 Oct 2016 |
Research output: Contribution to journal › Article › peer-review