War, antimicrobial resistance, and Acinetobacter baumannii (WAMRA)

A. Abou Fayad; O. El Diwachi; L.P. Haraoui; G. Abu Sitta; V.-K. Nguyen; A. Abbara; H. Landecker; N. Karah; C. Knapp; M. McEvoy; M. Zamman; P. Higgins; G. Matar

doi:10.1016/j.ijid.2020.09.255

War, antimicrobial resistance, and Acinetobacter baumannii (WAMRA)

A. Abou Fayad, O. El Diwachi, L.P. Haraoui, G. Abu Sitta, V.-K. Nguyen, A. Abbara, H. Landecker, N. Karah, C. Knapp, M. McEvoy, M. Zamman, P. Higgins, G. Matar

Civil And Environmental Engineering

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Abstract

Wars have been a great burden on humanity for a long period of time. The high medical costs of wars particularly those incurred in treating patients with multi-drug resistant infections is probably one of its most adverse effects. Acinetobacter baumannii is one of those superbugs which have gained much notoriety during times of wars for causing multi-drug resistant infections among injured military and civilian personnel. Since conflict regions are considered hot spots for heavy metals contamination, we hypothesize that exposure of A. baumannii to heavy metals coming from shelling and ammunition in war regions might be correlated with its increased levels of AMR. Therefore, herein we aim to investigate the effects of heavy metals on AMR of A. baumannii clinical isolates particularly those originating from war patients and determine the mechanisms implicated at the molecular level.

Original language	English
Pages (from-to)	87-88
Number of pages	2
Journal	International Journal of Infectious Diseases
Volume	101
Issue number	1
DOIs	https://doi.org/10.1016/j.ijid.2020.09.255
Publication status	Published - 1 Dec 2020
Event	International Congress on Infectious Diseases 2020 - Kuala Lumpur, Malaysia Duration: 10 Sept 2020 → 13 Sept 2020 https://isid.org/icid-september-cancelled/

Keywords

war
antimicrobial resistance
acinetobacter baumannii
WAMRA

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10.1016/j.ijid.2020.09.255Licence: CC BY-NC-ND 4.0

Fayad-etal-IJID-2021-War-antimicrobial-resistance-acinetobacter-baumanniiFinal published version, 366 KBLicence: CC BY-NC-ND 4.0

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title = "War, antimicrobial resistance, and Acinetobacter baumannii (WAMRA)",

abstract = "Wars have been a great burden on humanity for a long period of time. The high medical costs of wars particularly those incurred in treating patients with multi-drug resistant infections is probably one of its most adverse effects. Acinetobacter baumannii is one of those superbugs which have gained much notoriety during times of wars for causing multi-drug resistant infections among injured military and civilian personnel. Since conflict regions are considered hot spots for heavy metals contamination, we hypothesize that exposure of A. baumannii to heavy metals coming from shelling and ammunition in war regions might be correlated with its increased levels of AMR. Therefore, herein we aim to investigate the effects of heavy metals on AMR of A. baumannii clinical isolates particularly those originating from war patients and determine the mechanisms implicated at the molecular level.",

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language = "English",

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TY - JOUR

T1 - War, antimicrobial resistance, and Acinetobacter baumannii (WAMRA)

AU - Abou Fayad, A.

AU - El Diwachi, O.

AU - Haraoui, L.P.

AU - Abu Sitta, G.

AU - Nguyen, V.-K.

AU - Abbara, A.

AU - Landecker, H.

AU - Karah, N.

AU - Knapp, C.

AU - McEvoy, M.

AU - Zamman, M.

AU - Higgins, P.

AU - Matar, G.

PY - 2020/12/1

Y1 - 2020/12/1

N2 - Wars have been a great burden on humanity for a long period of time. The high medical costs of wars particularly those incurred in treating patients with multi-drug resistant infections is probably one of its most adverse effects. Acinetobacter baumannii is one of those superbugs which have gained much notoriety during times of wars for causing multi-drug resistant infections among injured military and civilian personnel. Since conflict regions are considered hot spots for heavy metals contamination, we hypothesize that exposure of A. baumannii to heavy metals coming from shelling and ammunition in war regions might be correlated with its increased levels of AMR. Therefore, herein we aim to investigate the effects of heavy metals on AMR of A. baumannii clinical isolates particularly those originating from war patients and determine the mechanisms implicated at the molecular level.

AB - Wars have been a great burden on humanity for a long period of time. The high medical costs of wars particularly those incurred in treating patients with multi-drug resistant infections is probably one of its most adverse effects. Acinetobacter baumannii is one of those superbugs which have gained much notoriety during times of wars for causing multi-drug resistant infections among injured military and civilian personnel. Since conflict regions are considered hot spots for heavy metals contamination, we hypothesize that exposure of A. baumannii to heavy metals coming from shelling and ammunition in war regions might be correlated with its increased levels of AMR. Therefore, herein we aim to investigate the effects of heavy metals on AMR of A. baumannii clinical isolates particularly those originating from war patients and determine the mechanisms implicated at the molecular level.

KW - war

KW - antimicrobial resistance

KW - acinetobacter baumannii

KW - WAMRA

UR - https://isid.org/icid-september-cancelled/

U2 - 10.1016/j.ijid.2020.09.255

DO - 10.1016/j.ijid.2020.09.255

M3 - Conference abstract

SN - 1201-9712

VL - 101

SP - 87

EP - 88

JO - International Journal of Infectious Diseases

JF - International Journal of Infectious Diseases

IS - 1

T2 - International Congress on Infectious Diseases 2020

Y2 - 10 September 2020 through 13 September 2020

ER -

War, antimicrobial resistance, and Acinetobacter baumannii (WAMRA)

Abstract

Keywords

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Heavy metal toxicity in armed conflicts potentiates AMR in A. baumannii by selecting for antibiotic and heavy metal co-resistance mechanisms

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