Visual short-term memory binding in Alzheimer’s disease and depression

Mario A. Parra, Sharon Abrahams, Robert H. Logie, Sergio Della Sala

Research output: Contribution to journalArticle

45 Citations (Scopus)

Abstract

The differential diagnosis between Alzheimer's disease (AD) and major depression (MD) in the elderly can be problematic because the cognitive profile of the two conditions overlaps. Associative learning tasks seem to separate AD from MD. However, they are sensitive to the effects of normal ageing. Short-term memory-binding tasks have proved insensitive to the effects of normal ageing and highly sensitive to AD. However, they have not been used to differentiate AD from MD. The present study was aimed at investigating visual short-term memory binding in AD and MD. Fourteen AD patients, 14 patients with MD, and 14 healthy older adults were asked to perform a visual short-term memory binding task that investigated the retention of shapes, colors, or combinations of shapes and colors. Participants were to recognize changes occurring between two consecutive displays either in a single dimension (i.e., shape or color only) or in two dimensions (i.e., shape-color binding). Short-term memory performance for shape or color only was equivalent across groups. The only significant effect found was in short-term memory for shape-color binding and this was due to AD patients performing poorly in this condition only. The results extend previous findings in AD to visual short-term memory and suggest that the specific impairment in binding information in memory differentiates between the performance of AD and patients with MD.
LanguageEnglish
Pages1160-1169
Number of pages10
JournalJournal of Neurology
Volume257
Issue number7
DOIs
Publication statusPublished - Jul 2010

Fingerprint

Short-Term Memory
Alzheimer Disease
Depression
Color
Differential Diagnosis
Learning

Keywords

  • Alzheimer’s disease
  • major depression
  • short-term memory
  • memory binding
  • working memory
  • early detection

Cite this

Parra, Mario A. ; Abrahams, Sharon ; Logie, Robert H. ; Della Sala, Sergio. / Visual short-term memory binding in Alzheimer’s disease and depression. In: Journal of Neurology. 2010 ; Vol. 257, No. 7. pp. 1160-1169.
@article{27067dccab2044eaa4c7ad7f7720a222,
title = "Visual short-term memory binding in Alzheimer’s disease and depression",
abstract = "The differential diagnosis between Alzheimer's disease (AD) and major depression (MD) in the elderly can be problematic because the cognitive profile of the two conditions overlaps. Associative learning tasks seem to separate AD from MD. However, they are sensitive to the effects of normal ageing. Short-term memory-binding tasks have proved insensitive to the effects of normal ageing and highly sensitive to AD. However, they have not been used to differentiate AD from MD. The present study was aimed at investigating visual short-term memory binding in AD and MD. Fourteen AD patients, 14 patients with MD, and 14 healthy older adults were asked to perform a visual short-term memory binding task that investigated the retention of shapes, colors, or combinations of shapes and colors. Participants were to recognize changes occurring between two consecutive displays either in a single dimension (i.e., shape or color only) or in two dimensions (i.e., shape-color binding). Short-term memory performance for shape or color only was equivalent across groups. The only significant effect found was in short-term memory for shape-color binding and this was due to AD patients performing poorly in this condition only. The results extend previous findings in AD to visual short-term memory and suggest that the specific impairment in binding information in memory differentiates between the performance of AD and patients with MD.",
keywords = "Alzheimer’s disease, major depression, short-term memory, memory binding, working memory, early detection",
author = "Parra, {Mario A.} and Sharon Abrahams and Logie, {Robert H.} and {Della Sala}, Sergio",
year = "2010",
month = "7",
doi = "10.1007/s00415-010-5484-9",
language = "English",
volume = "257",
pages = "1160--1169",
journal = "Journal of Neurology",
issn = "0340-5354",
number = "7",

}

Visual short-term memory binding in Alzheimer’s disease and depression. / Parra, Mario A.; Abrahams, Sharon; Logie, Robert H.; Della Sala, Sergio.

In: Journal of Neurology, Vol. 257, No. 7, 07.2010, p. 1160-1169.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Visual short-term memory binding in Alzheimer’s disease and depression

AU - Parra, Mario A.

AU - Abrahams, Sharon

AU - Logie, Robert H.

AU - Della Sala, Sergio

PY - 2010/7

Y1 - 2010/7

N2 - The differential diagnosis between Alzheimer's disease (AD) and major depression (MD) in the elderly can be problematic because the cognitive profile of the two conditions overlaps. Associative learning tasks seem to separate AD from MD. However, they are sensitive to the effects of normal ageing. Short-term memory-binding tasks have proved insensitive to the effects of normal ageing and highly sensitive to AD. However, they have not been used to differentiate AD from MD. The present study was aimed at investigating visual short-term memory binding in AD and MD. Fourteen AD patients, 14 patients with MD, and 14 healthy older adults were asked to perform a visual short-term memory binding task that investigated the retention of shapes, colors, or combinations of shapes and colors. Participants were to recognize changes occurring between two consecutive displays either in a single dimension (i.e., shape or color only) or in two dimensions (i.e., shape-color binding). Short-term memory performance for shape or color only was equivalent across groups. The only significant effect found was in short-term memory for shape-color binding and this was due to AD patients performing poorly in this condition only. The results extend previous findings in AD to visual short-term memory and suggest that the specific impairment in binding information in memory differentiates between the performance of AD and patients with MD.

AB - The differential diagnosis between Alzheimer's disease (AD) and major depression (MD) in the elderly can be problematic because the cognitive profile of the two conditions overlaps. Associative learning tasks seem to separate AD from MD. However, they are sensitive to the effects of normal ageing. Short-term memory-binding tasks have proved insensitive to the effects of normal ageing and highly sensitive to AD. However, they have not been used to differentiate AD from MD. The present study was aimed at investigating visual short-term memory binding in AD and MD. Fourteen AD patients, 14 patients with MD, and 14 healthy older adults were asked to perform a visual short-term memory binding task that investigated the retention of shapes, colors, or combinations of shapes and colors. Participants were to recognize changes occurring between two consecutive displays either in a single dimension (i.e., shape or color only) or in two dimensions (i.e., shape-color binding). Short-term memory performance for shape or color only was equivalent across groups. The only significant effect found was in short-term memory for shape-color binding and this was due to AD patients performing poorly in this condition only. The results extend previous findings in AD to visual short-term memory and suggest that the specific impairment in binding information in memory differentiates between the performance of AD and patients with MD.

KW - Alzheimer’s disease

KW - major depression

KW - short-term memory

KW - memory binding

KW - working memory

KW - early detection

UR - http://www.scopus.com/inward/record.url?scp=77954386894&partnerID=8YFLogxK

U2 - 10.1007/s00415-010-5484-9

DO - 10.1007/s00415-010-5484-9

M3 - Article

VL - 257

SP - 1160

EP - 1169

JO - Journal of Neurology

T2 - Journal of Neurology

JF - Journal of Neurology

SN - 0340-5354

IS - 7

ER -