Visceral leishmaniasis in the BALB/c mouse

a comparison of the in vivo activity of five non-ionic surfactant vesicle preparations of sodium stibogluconate.

Denise M Williams, K. C. Carter, A. J. Baillie

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Five non-ionic surfactants (Surfactants V-IX) were screened for their ability to produce vesicles for the delivery of sodium stibogluconate. Mean vesicle diameter and antimony content were determined prior to in vivo assessment of antiparasitic activity in a mouse model of acute visceral leishmaniasis. V/D suspensions (i.e. stibogluconate loaded vesicles kept in the hydrating drug solution) were more effective against spleen, liver and bone marrow parasites than drug loaded vesicle suspensions that had unentrapped drug removed. A Surfactant IX V/D suspension was the most active antileishmanial preparation causing 74 +/- 10%, 99 +/- 1% and 38 +/- 8% suppression of liver, spleen and bone marrow parasite burdens respectively. Contrary to previous findings, a reduction in splenic and bone marrow parasite burdens was achieved using large vesicles (mean diameter > 800nm). The significance of these results is discussed.
Original languageEnglish
Pages (from-to)1-7
Number of pages7
JournalJournal of Drug Targeting
Volume3
Issue number1
DOIs
Publication statusPublished - 1995

Fingerprint

Antimony Sodium Gluconate
Visceral Leishmaniasis
Surface-Active Agents
Suspensions
Parasites
Bone Marrow
Spleen
Pharmaceutical Preparations
Antiparasitic Agents
Antimony
Liver

Keywords

  • Leishmania donovani
  • murine model
  • drug delivery
  • non-ionic surfactant vesicle
  • niosomes
  • sodium stibogluconate

Cite this

@article{b80c41be1b9846c4835af8f779fff4c2,
title = "Visceral leishmaniasis in the BALB/c mouse: a comparison of the in vivo activity of five non-ionic surfactant vesicle preparations of sodium stibogluconate.",
abstract = "Five non-ionic surfactants (Surfactants V-IX) were screened for their ability to produce vesicles for the delivery of sodium stibogluconate. Mean vesicle diameter and antimony content were determined prior to in vivo assessment of antiparasitic activity in a mouse model of acute visceral leishmaniasis. V/D suspensions (i.e. stibogluconate loaded vesicles kept in the hydrating drug solution) were more effective against spleen, liver and bone marrow parasites than drug loaded vesicle suspensions that had unentrapped drug removed. A Surfactant IX V/D suspension was the most active antileishmanial preparation causing 74 +/- 10{\%}, 99 +/- 1{\%} and 38 +/- 8{\%} suppression of liver, spleen and bone marrow parasite burdens respectively. Contrary to previous findings, a reduction in splenic and bone marrow parasite burdens was achieved using large vesicles (mean diameter > 800nm). The significance of these results is discussed.",
keywords = "Leishmania donovani, murine model, drug delivery, non-ionic surfactant vesicle, niosomes, sodium stibogluconate",
author = "Williams, {Denise M} and Carter, {K. C.} and Baillie, {A. J.}",
year = "1995",
doi = "10.3109/10611869509015926",
language = "English",
volume = "3",
pages = "1--7",
journal = "Journal of Drug Targeting",
issn = "1061-186X",
number = "1",

}

TY - JOUR

T1 - Visceral leishmaniasis in the BALB/c mouse

T2 - a comparison of the in vivo activity of five non-ionic surfactant vesicle preparations of sodium stibogluconate.

AU - Williams, Denise M

AU - Carter, K. C.

AU - Baillie, A. J.

PY - 1995

Y1 - 1995

N2 - Five non-ionic surfactants (Surfactants V-IX) were screened for their ability to produce vesicles for the delivery of sodium stibogluconate. Mean vesicle diameter and antimony content were determined prior to in vivo assessment of antiparasitic activity in a mouse model of acute visceral leishmaniasis. V/D suspensions (i.e. stibogluconate loaded vesicles kept in the hydrating drug solution) were more effective against spleen, liver and bone marrow parasites than drug loaded vesicle suspensions that had unentrapped drug removed. A Surfactant IX V/D suspension was the most active antileishmanial preparation causing 74 +/- 10%, 99 +/- 1% and 38 +/- 8% suppression of liver, spleen and bone marrow parasite burdens respectively. Contrary to previous findings, a reduction in splenic and bone marrow parasite burdens was achieved using large vesicles (mean diameter > 800nm). The significance of these results is discussed.

AB - Five non-ionic surfactants (Surfactants V-IX) were screened for their ability to produce vesicles for the delivery of sodium stibogluconate. Mean vesicle diameter and antimony content were determined prior to in vivo assessment of antiparasitic activity in a mouse model of acute visceral leishmaniasis. V/D suspensions (i.e. stibogluconate loaded vesicles kept in the hydrating drug solution) were more effective against spleen, liver and bone marrow parasites than drug loaded vesicle suspensions that had unentrapped drug removed. A Surfactant IX V/D suspension was the most active antileishmanial preparation causing 74 +/- 10%, 99 +/- 1% and 38 +/- 8% suppression of liver, spleen and bone marrow parasite burdens respectively. Contrary to previous findings, a reduction in splenic and bone marrow parasite burdens was achieved using large vesicles (mean diameter > 800nm). The significance of these results is discussed.

KW - Leishmania donovani

KW - murine model

KW - drug delivery

KW - non-ionic surfactant vesicle

KW - niosomes

KW - sodium stibogluconate

U2 - 10.3109/10611869509015926

DO - 10.3109/10611869509015926

M3 - Article

VL - 3

SP - 1

EP - 7

JO - Journal of Drug Targeting

JF - Journal of Drug Targeting

SN - 1061-186X

IS - 1

ER -