Visceral leishmaniasis: drug carrier characteristics and the ability to clear parasites from the liver, spleen and bone marrow in Leishmani donovani infected BALB/c mice

K. C. Carter, T. F. Dolan, J. Alexander , A.J. Baillie, C McColgan

Research output: Contribution to journalArticlepeer-review

53 Citations (Scopus)


The efficacy of various sodium stibogluconate formulations against Leishmania donovani has been investigated using a BALB/c mouse model of visceral leishmaniasis. Only one therapy, multiple dosing with drug loaded sonicated vesicles, liposomes or niosomes, was found to be effective against parasites in the liver, spleen and bone marrow. Other treatments significantly reduced parasite liver burdens but either failed to effect spleen and bone marrow parasites, or were effective but toxic. Prophylactic treatment with sodium stibogluconate preparations, six days before infection, reduced parasite multiplication in the liver (free, niosomal and liposomal drug) and the spleen (sonicated, drug loaded niosomes only), but had no suppressive effect on bone marrow parasite burdens compared with controls. These results indicate that in-vivo sodium stibogluconate persists in some compartments at parasiticidal concentrations and that failure to reach this concentration at some sites of infection such as bone marrow, is the cause of treatment failure and relapse.
Original languageEnglish
Pages (from-to)87-91
Number of pages5
JournalJournal of Pharmacy and Pharmacology
Issue number2
Publication statusPublished - 1 Feb 1989


  • visceral leishmaniasis
  • parasites
  • mice
  • Leishmania donovani
  • sodium stibogluconate

Cite this