Viedma ripening: a reliable crystallisation method to reach single chirality

Leyla-Cann Sögütoglu; René R. E. Steendam; Hugo Meekes; Elias Vlieg; Floris P. J. T. Rutjes

doi:10.1039/c5cs00196j

Viedma ripening: a reliable crystallisation method to reach single chirality

Leyla-Cann Sögütoglu, René R. E. Steendam, Hugo Meekes, Elias Vlieg, Floris P. J. T. Rutjes

Strathclyde Institute Of Pharmacy And Biomedical Sciences

Research output: Contribution to journal › Article › peer-review

179 Citations (Scopus)

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Abstract

Crystallisation processes have evolved to practical methods that allow isolation of an enantiopure product in high yield. Viedma ripening in particular enables access to enantiopure products in a reliable way, simply through grinding of crystals in a solution. This tutorial review covers the basic principles behind asymmetric crystallisation processes, with an emphasis on Viedma ripening, and shows that to date many novel organic molecules can be obtained in enantiopure solid form.

Original language	English
Pages (from-to)	6723-6732
Number of pages	10
Journal	Chemical Society Reviews
Volume	44
Issue number	19
DOIs	https://doi.org/10.1039/c5cs00196j
Publication status	Published - 7 Oct 2015

Keywords

crystallisation process
Viedma ripening
crystal growth
molecular chirality

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Viedma ripening: a reliable crystallisation method to reach single chirality

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Keywords

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