Viedma ripening: a reliable crystallisation method to reach single chirality

Leyla-Cann Sögütoglu, René R. E. Steendam, Hugo Meekes, Elias Vlieg, Floris P. J. T. Rutjes

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Abstract

Crystallisation processes have evolved to practical methods that allow isolation of an enantiopure product in high yield. Viedma ripening in particular enables access to enantiopure products in a reliable way, simply through grinding of crystals in a solution. This tutorial review covers the basic principles behind asymmetric crystallisation processes, with an emphasis on Viedma ripening, and shows that to date many novel organic molecules can be obtained in enantiopure solid form.

Original languageEnglish
Pages (from-to)6723-6732
Number of pages10
JournalChemical Society Reviews
Volume44
Issue number19
DOIs
Publication statusPublished - 7 Oct 2015

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Keywords

  • crystallisation process
  • Viedma ripening
  • crystal growth
  • molecular chirality

Cite this

Sögütoglu, L-C., Steendam, R. R. E., Meekes, H., Vlieg, E., & Rutjes, F. P. J. T. (2015). Viedma ripening: a reliable crystallisation method to reach single chirality. Chemical Society Reviews, 44(19), 6723-6732. https://doi.org/10.1039/c5cs00196j