Vibrational spectroscopic methods for cytology and cellular research

Graeme Clemens, James R. Hands, Konrad M. Dorling, Matthew J. Baker

Research output: Contribution to journalArticle

57 Citations (Scopus)

Abstract

The use of vibrational spectroscopy, FTIR and Raman, for cytology and cellular research has the potential to revolutionise the approach to cellular analysis. Vibrational spectroscopy is non-destructive, simple to operate and provides direct information. Importantly it does not require expensive exogenous labels that may affect the chemistry of the cell under analysis. In addition, the advent of spectroscopic microscopes provides the ability to image cells and acquire spectra with a subcellular resolution. This introductory review focuses on recent developments within this fast paced field and highlights potential for the future use of FTIR and Raman spectroscopy. We particularly focus on the development of live cell research and the new technologies and methodologies that have enabled this.

Original languageEnglish
Pages (from-to)4411-4444
Number of pages34
JournalAnalyst
Volume139
Issue number18
Early online date27 Jun 2014
DOIs
Publication statusPublished - 21 Sep 2014

Keywords

  • vibrational spectroscopy
  • cytology
  • cellular research

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