VGLUT2 functions as a differential marker for hippocampal output neurons

Christian Wozny; Prateep Beed; Noam Nitzan; Yona Pössnecker; Benjamin R. Rost; Dietmar Schmitz

doi:10.3389/fncel.2018.00337

VGLUT2 functions as a differential marker for hippocampal output neurons

Christian Wozny, Prateep Beed, Noam Nitzan, Yona Pössnecker, Benjamin R. Rost, Dietmar Schmitz

Strathclyde Institute Of Pharmacy And Biomedical Sciences

Research output: Contribution to journal › Article › peer-review

24 Citations (Scopus)

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Abstract

The subiculum is the gatekeeper between the hippocampus and cortical areas. Yet, the lack of a pyramidal cell-specific marker gene has made the analysis of the subicular area very difficult. Here we report that the vesicular-glutamate transporter 2 (VGLUT2) functions as a specific marker gene for subicular burst-firing neurons, and demonstrate that VGLUT2-Cre mice allow for Channelrhodopsin-2 (ChR2)-assisted connectivity analysis.

Original language	English
Article number	337
Number of pages	5
Journal	Frontiers in Cellular Neuroscience
Volume	12
DOIs	https://doi.org/10.3389/fncel.2018.00337
Publication status	Published - 2 Oct 2018

Keywords

channelrhodopsin-2
entorhinal cortex
hippocampus
subiculum
synaptic transmission
VGLUT2

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10.3389/fncel.2018.00337

Wozny-etal-FCN-2018-VGLUT2-functions-as-a-differential-marker-for-hippocampalFinal published version, 1.25 MBLicence: CC BY 4.0

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title = "VGLUT2 functions as a differential marker for hippocampal output neurons",

abstract = "The subiculum is the gatekeeper between the hippocampus and cortical areas. Yet, the lack of a pyramidal cell-specific marker gene has made the analysis of the subicular area very difficult. Here we report that the vesicular-glutamate transporter 2 (VGLUT2) functions as a specific marker gene for subicular burst-firing neurons, and demonstrate that VGLUT2-Cre mice allow for Channelrhodopsin-2 (ChR2)-assisted connectivity analysis.",

keywords = "channelrhodopsin-2, entorhinal cortex, hippocampus, subiculum, synaptic transmission, VGLUT2",

author = "Christian Wozny and Prateep Beed and Noam Nitzan and Yona P{\"o}ssnecker and Rost, \{Benjamin R.\} and Dietmar Schmitz",

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T1 - VGLUT2 functions as a differential marker for hippocampal output neurons

AU - Wozny, Christian

AU - Beed, Prateep

AU - Nitzan, Noam

AU - Pössnecker, Yona

AU - Rost, Benjamin R.

AU - Schmitz, Dietmar

PY - 2018/10/2

Y1 - 2018/10/2

N2 - The subiculum is the gatekeeper between the hippocampus and cortical areas. Yet, the lack of a pyramidal cell-specific marker gene has made the analysis of the subicular area very difficult. Here we report that the vesicular-glutamate transporter 2 (VGLUT2) functions as a specific marker gene for subicular burst-firing neurons, and demonstrate that VGLUT2-Cre mice allow for Channelrhodopsin-2 (ChR2)-assisted connectivity analysis.

AB - The subiculum is the gatekeeper between the hippocampus and cortical areas. Yet, the lack of a pyramidal cell-specific marker gene has made the analysis of the subicular area very difficult. Here we report that the vesicular-glutamate transporter 2 (VGLUT2) functions as a specific marker gene for subicular burst-firing neurons, and demonstrate that VGLUT2-Cre mice allow for Channelrhodopsin-2 (ChR2)-assisted connectivity analysis.

KW - channelrhodopsin-2

KW - entorhinal cortex

KW - hippocampus

KW - subiculum

KW - synaptic transmission

KW - VGLUT2

U2 - 10.3389/fncel.2018.00337

DO - 10.3389/fncel.2018.00337

M3 - Article

C2 - 30333731

SN - 1662-5102

VL - 12

JO - Frontiers in Cellular Neuroscience

JF - Frontiers in Cellular Neuroscience

M1 - 337

ER -

VGLUT2 functions as a differential marker for hippocampal output neurons

Abstract

Keywords

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