The subiculum is the gatekeeper between the hippocampus and cortical areas. Yet, the lack of a pyramidal cell-specific marker gene has made the analysis of the subicular area very difficult. Here we report that the vesicular-glutamate transporter 2 (VGLUT2) functions as a specific marker gene for subicular burst-firing neurons, and demonstrate that VGLUT2-Cre mice allow for Channelrhodopsin-2 (ChR2)-assisted connectivity analysis.
- entorhinal cortex
- synaptic transmission
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- Health and Wellbeing
- Strathclyde Institute Of Pharmacy And Biomedical Sciences - Visiting Professor
Person: Visiting Professor