The subiculum is the gatekeeper between the hippocampus and cortical areas. Yet, the lack of a pyramidal cell-specific marker gene has made the analysis of the subicular area very difficult. Here we report that the vesicular-glutamate transporter 2 (VGLUT2) functions as a specific marker gene for subicular burst-firing neurons, and demonstrate that VGLUT2-Cre mice allow for Channelrhodopsin-2 (ChR2)-assisted connectivity analysis.
- entorhinal cortex
- synaptic transmission
Wozny, C., Beed, P., Nitzan, N., Pössnecker, Y., Rost, B. R., & Schmitz, D. (2018). VGLUT2 functions as a differential marker for hippocampal output neurons. Frontiers in Cellular Neuroscience, 12, . https://doi.org/10.3389/fncel.2018.00337