VGLUT2 functions as a differential marker for hippocampal output neurons

Christian Wozny, Prateep Beed, Noam Nitzan, Yona Pössnecker, Benjamin R. Rost, Dietmar Schmitz

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Abstract

The subiculum is the gatekeeper between the hippocampus and cortical areas. Yet, the lack of a pyramidal cell-specific marker gene has made the analysis of the subicular area very difficult. Here we report that the vesicular-glutamate transporter 2 (VGLUT2) functions as a specific marker gene for subicular burst-firing neurons, and demonstrate that VGLUT2-Cre mice allow for Channelrhodopsin-2 (ChR2)-assisted connectivity analysis.
Original languageEnglish
Article number337
Number of pages5
JournalFrontiers in Cellular Neuroscience
Volume12
DOIs
Publication statusPublished - 2 Oct 2018

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Keywords

  • channelrhodopsin-2
  • entorhinal cortex
  • hippocampus
  • subiculum
  • synaptic transmission
  • VGLUT2

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