Versatile pectin grafted poly (N-isopropylacrylamide): modulated targeted drug release

Shereen M. Assaf, Yousef M. Abul-Haija, Mohammad M. Fares

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

This study describes synthesis and optimization of pectin grafted poly(N-isopropylacrylamide) hydrogels as vehicles for colon-targeted theophylline model drug release. The gels were prepared in the presence of N, N′–methylenebisacrylamide (MBAA) crosslinker and ceric ammonium nitrate (CAN) initiator under N2 atmosphere. Optimum conditions, in terms of percent of grafting (%G), were determined as follows: pectin = 1.0 g, [NIPAAm] = 26.51 mM, [MBAA] = 0.65 mM, [CAN] = 0.073 mM, polymerization temperature = 30°C and time = 4.0 h. Hydrogels were characterized by FTIR, TGA, DSC, XRD and SEM. The formed hydrogel did not have a thermo-sensitivity behavior. The in vitro percent drug release was studied in terms of different percent of grafting and different polymerization temperatures under two pH values namely 5.5 and 7.4. Conclusively, the optimum colon-targeted vehicle properties that provide the least drug release at pH5.5 and the most drug release at pH7.4 were as follows: [NIPAAm] = 26.51 mM and [MBAA] = 0.56 mM, polymerization temperature = 30°C and %G = 55.5.
LanguageEnglish
Pages493-502
Number of pages10
JournalJournal of Macromolecular Science Part A Pure and Applied Chemistry
Volume48
Issue number6
DOIs
Publication statusPublished - 2011

Fingerprint

Hydrogels
Polymerization
Nitrates
Pharmaceutical Preparations
Temperature
Hydrogel
Gels
Theophylline
Scanning electron microscopy
pectin
poly-N-isopropylacrylamide
ceric ammonium nitrate

Keywords

  • poly (N-isopropylacrylamide)
  • versatile
  • pectin
  • grafted
  • targeted drug release
  • modulated

Cite this

Assaf, Shereen M. ; Abul-Haija, Yousef M. ; Fares, Mohammad M. / Versatile pectin grafted poly (N-isopropylacrylamide) : modulated targeted drug release. In: Journal of Macromolecular Science Part A Pure and Applied Chemistry . 2011 ; Vol. 48, No. 6. pp. 493-502.
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Versatile pectin grafted poly (N-isopropylacrylamide) : modulated targeted drug release. / Assaf, Shereen M.; Abul-Haija, Yousef M.; Fares, Mohammad M.

In: Journal of Macromolecular Science Part A Pure and Applied Chemistry , Vol. 48, No. 6, 2011, p. 493-502.

Research output: Contribution to journalArticle

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