Versatile pectin grafted poly (N-isopropylacrylamide): modulated targeted drug release

Shereen M. Assaf, Yousef M. Abul-Haija, Mohammad M. Fares

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

This study describes synthesis and optimization of pectin grafted poly(N-isopropylacrylamide) hydrogels as vehicles for colon-targeted theophylline model drug release. The gels were prepared in the presence of N, N′–methylenebisacrylamide (MBAA) crosslinker and ceric ammonium nitrate (CAN) initiator under N2 atmosphere. Optimum conditions, in terms of percent of grafting (%G), were determined as follows: pectin = 1.0 g, [NIPAAm] = 26.51 mM, [MBAA] = 0.65 mM, [CAN] = 0.073 mM, polymerization temperature = 30°C and time = 4.0 h. Hydrogels were characterized by FTIR, TGA, DSC, XRD and SEM. The formed hydrogel did not have a thermo-sensitivity behavior. The in vitro percent drug release was studied in terms of different percent of grafting and different polymerization temperatures under two pH values namely 5.5 and 7.4. Conclusively, the optimum colon-targeted vehicle properties that provide the least drug release at pH5.5 and the most drug release at pH7.4 were as follows: [NIPAAm] = 26.51 mM and [MBAA] = 0.56 mM, polymerization temperature = 30°C and %G = 55.5.
Original languageEnglish
Pages (from-to)493-502
Number of pages10
JournalJournal of Macromolecular Science Part A Pure and Applied Chemistry
Volume48
Issue number6
DOIs
Publication statusPublished - 2011

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Keywords

  • poly (N-isopropylacrylamide)
  • versatile
  • pectin
  • grafted
  • targeted drug release
  • modulated

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