Variation in form and function: the helix-turn-helix regulators of the GntR superfamily

P. Hoskisson, S. Rigali, A.I. Laskin (Editor), S. Sariaslani (Editor), G.M. Gadd (Editor)

Research output: Chapter in Book/Report/Conference proceedingChapter

82 Citations (Scopus)

Abstract

One of the most abundant and widely distributed groups of Helix-turn-helix (HTH) transcription factors is the metabolite-responsive GntR family of regulators (>8500 members in the Pfam database; Jan 2009). These proteins contain a DNA-binding HTH domain at the N terminus of the protein and an effector-binding and/or oligomerisation domain at the C terminus, where upon on binding an effector molecule, a conformational change occurs in the protein which influences the DNA-binding properties of the regulator resulting in repression or activation of transcription. This review summarises what we know about the distribution, structure, function and classification of these regulators and suggests that they may have a future role in biotechnology.
LanguageEnglish
Title of host publicationAdvances in Applied Microbiology
Pages1-22
Number of pages22
Volume69
DOIs
Publication statusPublished - 2009

Publication series

NameAdvances in Applied Microbiology
PublisherElsevier

Fingerprint

DNA
Biotechnology
Protein Binding
Transcriptional Activation
Proteins
Transcription Factors
Databases

Keywords

  • GntR
  • helix-turn-helix
  • repressor protein
  • dna binding
  • autoregulation
  • streptomyces

Cite this

Hoskisson, P., Rigali, S., Laskin, A. I. (Ed.), Sariaslani, S. (Ed.), & Gadd, G. M. (Ed.) (2009). Variation in form and function: the helix-turn-helix regulators of the GntR superfamily. In Advances in Applied Microbiology (Vol. 69, pp. 1-22). (Advances in Applied Microbiology). https://doi.org/10.1016/S0065-2164(09)69001-8
Hoskisson, P. ; Rigali, S. ; Laskin, A.I. (Editor) ; Sariaslani, S. (Editor) ; Gadd, G.M. (Editor). / Variation in form and function: the helix-turn-helix regulators of the GntR superfamily. Advances in Applied Microbiology. Vol. 69 2009. pp. 1-22 (Advances in Applied Microbiology).
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Hoskisson, P, Rigali, S, Laskin, AI (ed.), Sariaslani, S (ed.) & Gadd, GM (ed.) 2009, Variation in form and function: the helix-turn-helix regulators of the GntR superfamily. in Advances in Applied Microbiology. vol. 69, Advances in Applied Microbiology, pp. 1-22. https://doi.org/10.1016/S0065-2164(09)69001-8

Variation in form and function: the helix-turn-helix regulators of the GntR superfamily. / Hoskisson, P.; Rigali, S.; Laskin, A.I. (Editor); Sariaslani, S. (Editor); Gadd, G.M. (Editor).

Advances in Applied Microbiology. Vol. 69 2009. p. 1-22 (Advances in Applied Microbiology).

Research output: Chapter in Book/Report/Conference proceedingChapter

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Hoskisson P, Rigali S, Laskin AI, (ed.), Sariaslani S, (ed.), Gadd GM, (ed.). Variation in form and function: the helix-turn-helix regulators of the GntR superfamily. In Advances in Applied Microbiology. Vol. 69. 2009. p. 1-22. (Advances in Applied Microbiology). https://doi.org/10.1016/S0065-2164(09)69001-8