Validation of a vascular access specific quality of life measure (VASQoL)

Sabine Richarz, Sharon Greenwood, David B Kingsmore, Peter C Thomson, Mark Dunlop, Matt-Mouley Bouamrane, Ramsay Meiklem, Karen Stevenson

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Abstract

Background
A self-administered 11 item Vascular Access Specific Quality of Life Measure (VASQoL) was previously derived from detailed qualitative interviews with adult patients with kidney failure who have experienced vascular access using the Capabilities Approach as a theoretical base1. This study reports the psychometric validation of the VASQoL measure including its reliability, content validity and responsiveness to change.

Methods
Cognitive interviews were conducted with 23 adult patients with kidney failure after completion of the VASQoL measure. Focus group discussion with a vascular access professional multidisciplinary team was undertaken (n=8) and subsequently a further 101 adult kidney failure patients with vascular access (TCVC, AVF or AVG) completed the digital VASQoL measure, EQ-5D and SF-36 questionnaires in a longitudinal study with prospectively recorded vascular access events.

Results
Transcript analysis of cognitive interviews after VASQoL completion indicated that the content was comprehensive and well understood by participants. Assessment of Internal reliability for the VASQoL measure was high (Cronbach’s alpha 0.858). Test-retest reliability of the overall

VASQoL measure was high (intra class correlation coefficient 0.916). In those patients who experienced a vascular access event, significant differences were observed in paired analysis of the VASQoL physical domain questions and vascular access function domain questions and in the EQ-5D usual activities, pain and anxiety domains. In those with no vascular access event, variation was observed in longitudinal analysis in VASQoL questions relating to worry about VA function and capability domains, whilst no variation was observed in the EQ5D measure.

Conclusion
The VASQoL measure has good internal consistency, test-retest reliability, convergent validity and responsiveness to change for clinically relevant vascular access outcomes. This provides a validated, vascular access specific quality of life measure that can be used in future trials of vascular access, evaluation of new technologies and routine use as a patient reported outcome measure (PROM).
Original languageEnglish
Pages (from-to)702-714
Number of pages12
JournalThe Journal of Vascular Access
Volume24
Issue number4
Early online date5 Oct 2021
DOIs
Publication statusPublished - 1 Jul 2023

Keywords

  • kidney failure
  • vascular access
  • life measure

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