UV-induced 1,3,4-oxadiazole formation from 5-substituted tetrazoles and carboxylic acids in flow

Luke Green, Keith Livingstone, Sophie Bertrand, Simon Peace, Craig Jamieson

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)
23 Downloads (Pure)

Abstract

A range of 1,3,4-oxadiazoles have been synthesized using a UV-B activated flow approach starting from carboxylic acids and 5-substituted tetrazoles. The application of UV light represents an attractive alternative to the traditional thermolytic approach and has demonstrated comparable efficiency and versatility, with a diverse substrate scope, including the incorporation of highly substituted amino acids.
Original languageEnglish
Pages (from-to)14866-14870
Number of pages5
JournalChemistry - A European Journal
Volume26
Issue number65
Early online date12 Aug 2020
DOIs
Publication statusPublished - 20 Nov 2020

Keywords

  • UV-B activated flow
  • 1,3,4-oxadiazoles
  • carboxylic acids
  • 5-substituted tetrazoles

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