Utilisation of an electrochemiluminescence sensor for atropine determination in complex matrices

Research output: Contribution to journalArticle

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3 Downloads (Pure)

Abstract

A major challenge within forensic science is the development of accurate and robust methodologies that can be utilized on-site for detection at crime scenes and can be used for analyzing multiple sample types. The recent expansion of electrochemical sensors to tackle this hurdle requires sensors that can undergo analysis without any pretreatment. Given the vast array of samples that are submitted for forensic analysis, this can pose a major challenge for all electrochemical sensors, including electrochemiluminescent (ECL)-based sensors. Within this contribution, we demonstrate the capacity for an ECL-based sensor to address this challenge and it is potential to detect and quantify atropine from a wide range of samples directly from herbal material to spiked solutions. This portable platform demonstrates satisfactory analytical parameters with linearity across a concentration range of 0.75 to 100 μM, reproducibility of 3.0%, repeatability of 9.2%, and a detection limit of ∼0.75 μM. The sensor displays good selectivity toward alkaloid species and, in particular, the hallucinogenic tropane alkaloid functionality within complex matrices. This portable sensor provides rapid detection alongside low cost and operational simplicity, thus, providing a basis for the exploitation of ECL-based sensors within the forensic arena.

Original languageEnglish
Pages (from-to)12369-12376
Number of pages8
JournalAnalytical Chemistry
Volume91
Issue number19
Early online date22 Aug 2019
DOIs
Publication statusPublished - 1 Oct 2019

Keywords

  • electrochemical sensors
  • electrochemiluminescent based sensors
  • ECL
  • portable platform

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    Data for: "Utilisation of an Electrochemiluminescence Sensor for Atropine Determination in Complex Matrices"

    Dennany, L. (Creator), Brown, K. (Creator), Allan, P. (Creator), McMenemy, M. (Creator), Palmer, M. (Contributor), Baker, M. (Contributor) & Robinson, D. (Contributor), University of Strathclyde, 10 Sep 2019

    Dataset

    Activities

    • 1 Invited talk
    • 1 Oral presentation

    Mixed Luminophore ECL for the Differentiation Between Analytes of Similar Chemical Structure

    Lynn Dennany (Speaker), Kelly Brown (Speaker) & Pamela Allan (Contributor)

    22 Aug 201925 Aug 2019

    Activity: Talk or presentation typesOral presentation

    Illuminating Chemical Detection

    Lynn Dennany (Invited speaker)

    22 Aug 201925 Dec 2019

    Activity: Talk or presentation typesInvited talk

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