Using high-resolution contact networks to evaluate SARS-CoV-2 transmission and control in large-scale multi-day events

Singapore CruiseSafe working group; CMMID COVID-19 Working Group; Rachael Pung; Josh A. Firth; Lewis G. Spurgin; Annie Chang; Jade Kong; Jazzy Wong; Ooi Jo Jin; Deepa Selvaraj; Dominique Yong; Jocelyn Lang; Abilash Sivalingam; Simon R. Procter; Stefan Flasche; William Waites; Kiesha Prem; Carl A.B. Pearson; Hamish P. Gibbs; Katharine Sherratt; C. Julian Villabona-Arenas; Kerry L.M. Wong; Yang Liu; Paul Mee; Lloyd A.C. Chapman; Katherine E. Atkins; Matthew Quaife; James D. Munday; Sebastian Funk; Rosalind M. Eggo; Stèphane Huè; Nicholas G. Davies; David Hodgson; Kaja Abbas; Ciara V. McCarthy; Joel Hellewell; Sam Abbott; Nikos I. Bosse; Oliver Brady; Rosanna C. Barnard; Mark Jit; Damien C. Tully; Graham Medley; Fiona Yueqian Sun; Christopher I. Jarvis; Rachel Lowev; Kathleen O’Reilly; Sophie R. Meakin; Akira Endo; Frank G. Sandmann; W. John Edmunds; Mihaly Koltai

doi:10.1038/s41467-022-29522-y

Using high-resolution contact networks to evaluate SARS-CoV-2 transmission and control in large-scale multi-day events

Singapore CruiseSafe working group, CMMID COVID-19 Working Group, Rachael Pung^*, Josh A. Firth, Lewis G. Spurgin, Annie Chang, Jade Kong, Jazzy Wong, Ooi Jo Jin, Deepa Selvaraj, Dominique Yong, Jocelyn Lang, Abilash Sivalingam, Simon R. Procter, Stefan Flasche, William Waites, Kiesha Prem, Carl A.B. Pearson, Hamish P. Gibbs, Katharine SherrattC. Julian Villabona-Arenas, Kerry L.M. Wong, Yang Liu, Paul Mee, Lloyd A.C. Chapman, Katherine E. Atkins, Matthew Quaife, James D. Munday, Sebastian Funk, Rosalind M. Eggo, Stèphane Huè, Nicholas G. Davies, David Hodgson, Kaja Abbas, Ciara V. McCarthy, Joel Hellewell, Sam Abbott, Nikos I. Bosse, Oliver Brady, Rosanna C. Barnard, Mark Jit, Damien C. Tully, Graham Medley, Fiona Yueqian Sun, Christopher I. Jarvis, Rachel Lowev, Kathleen O’Reilly, Sophie R. Meakin, Akira Endo, Frank G. Sandmann, W. John Edmunds, Mihaly Koltai

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

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Abstract

The emergence of highly transmissible SARS-CoV-2 variants has created a need to reassess the risk posed by increasing social contacts as countries resume pre-pandemic activities, particularly in the context of resuming large-scale events over multiple days. To examine how social contacts formed in different activity settings influences interventions required to control Delta variant outbreaks, we collected high-resolution data on contacts among passengers and crew on cruise ships and combined the data with network transmission models. We found passengers had a median of 20 (IQR 10–36) unique close contacts per day, and over 60% of their contact episodes were made in dining or sports areas where mask wearing is typically limited. In simulated outbreaks, we found that vaccination coverage and rapid antigen tests had a larger effect than mask mandates alone, indicating the importance of combined interventions against Delta to reduce event risk in the vaccine era.

Original language	English
Article number	1956
Number of pages	11
Journal	Nature Communications
Volume	13
Issue number	1
Early online date	12 Apr 2022
DOIs	https://doi.org/10.1038/s41467-022-29522-y
Publication status	Published - 31 Dec 2022
Externally published	Yes

Funding

R.P. acknowledges funding from the Singapore Ministry of Health. J.A.F. was supported by a research fellowship from Merton College and BBSRC (BB/S009752/1) and acknowledges funding from NERC (NE/S010335/1). A.J.K. was supported by a Sir Henry Dale Fellowship jointly funded by the Wellcome Trust and the Royal Society (grant 206250/Z/17/Z).

Keywords

Covid-19
high resolution contact networks
SARS-CoV-2
transmission
control
large-scale multi-day events

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1038/s41467-022-29522-yLicence: CC BY 4.0

Pung-etal-NC-2022-Using-high-resolution-contact-networks-to-evaluate-SARS-CoV-2-transmissionFinal published version, 1.37 MBLicence: CC BY 4.0

Cite this

Singapore CruiseSafe working group, CMMID COVID-19 Working Group, Pung, R., Firth, J. A., Spurgin, L. G., Chang, A., Kong, J., Wong, J., Jin, O. J., Selvaraj, D., Yong, D., Lang, J., Sivalingam, A., Procter, S. R., Flasche, S., Waites, W., Prem, K., Pearson, C. A. B., Gibbs, H. P., ... Koltai, M. (2022). Using high-resolution contact networks to evaluate SARS-CoV-2 transmission and control in large-scale multi-day events. Nature Communications, 13(1), Article 1956. https://doi.org/10.1038/s41467-022-29522-y

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abstract = "The emergence of highly transmissible SARS-CoV-2 variants has created a need to reassess the risk posed by increasing social contacts as countries resume pre-pandemic activities, particularly in the context of resuming large-scale events over multiple days. To examine how social contacts formed in different activity settings influences interventions required to control Delta variant outbreaks, we collected high-resolution data on contacts among passengers and crew on cruise ships and combined the data with network transmission models. We found passengers had a median of 20 (IQR 10–36) unique close contacts per day, and over 60% of their contact episodes were made in dining or sports areas where mask wearing is typically limited. In simulated outbreaks, we found that vaccination coverage and rapid antigen tests had a larger effect than mask mandates alone, indicating the importance of combined interventions against Delta to reduce event risk in the vaccine era.",

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author = "{Singapore CruiseSafe working group} and {CMMID COVID-19 Working Group} and Rachael Pung and Firth, {Josh A.} and Spurgin, {Lewis G.} and Annie Chang and Jade Kong and Jazzy Wong and Jin, {Ooi Jo} and Deepa Selvaraj and Dominique Yong and Jocelyn Lang and Abilash Sivalingam and Procter, {Simon R.} and Stefan Flasche and William Waites and Kiesha Prem and Pearson, {Carl A.B.} and Gibbs, {Hamish P.} and Katharine Sherratt and Villabona-Arenas, {C. Julian} and Wong, {Kerry L.M.} and Yang Liu and Paul Mee and Chapman, {Lloyd A.C.} and Atkins, {Katherine E.} and Matthew Quaife and Munday, {James D.} and Sebastian Funk and Eggo, {Rosalind M.} and St{\`e}phane Hu{\`e} and Davies, {Nicholas G.} and David Hodgson and Kaja Abbas and McCarthy, {Ciara V.} and Joel Hellewell and Sam Abbott and Bosse, {Nikos I.} and Oliver Brady and Barnard, {Rosanna C.} and Mark Jit and Tully, {Damien C.} and Graham Medley and Sun, {Fiona Yueqian} and Jarvis, {Christopher I.} and Rachel Lowev and Kathleen O{\textquoteright}Reilly and Meakin, {Sophie R.} and Akira Endo and Sandmann, {Frank G.} and Edmunds, {W. John} and Mihaly Koltai",

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Singapore CruiseSafe working group, CMMID COVID-19 Working Group, Pung, R, Firth, JA, Spurgin, LG, Chang, A, Kong, J, Wong, J, Jin, OJ, Selvaraj, D, Yong, D, Lang, J, Sivalingam, A, Procter, SR, Flasche, S, Waites, W, Prem, K, Pearson, CAB, Gibbs, HP, Sherratt, K, Villabona-Arenas, CJ, Wong, KLM, Liu, Y, Mee, P, Chapman, LAC, Atkins, KE, Quaife, M, Munday, JD, Funk, S, Eggo, RM, Huè, S, Davies, NG, Hodgson, D, Abbas, K, McCarthy, CV, Hellewell, J, Abbott, S, Bosse, NI, Brady, O, Barnard, RC, Jit, M, Tully, DC, Medley, G, Sun, FY, Jarvis, CI, Lowev, R, O’Reilly, K, Meakin, SR, Endo, A, Sandmann, FG, Edmunds, WJ & Koltai, M 2022, 'Using high-resolution contact networks to evaluate SARS-CoV-2 transmission and control in large-scale multi-day events', Nature Communications, vol. 13, no. 1, 1956. https://doi.org/10.1038/s41467-022-29522-y

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T1 - Using high-resolution contact networks to evaluate SARS-CoV-2 transmission and control in large-scale multi-day events

AU - Singapore CruiseSafe working group

AU - CMMID COVID-19 Working Group

AU - Pung, Rachael

AU - Firth, Josh A.

AU - Spurgin, Lewis G.

AU - Chang, Annie

AU - Kong, Jade

AU - Wong, Jazzy

AU - Jin, Ooi Jo

AU - Selvaraj, Deepa

AU - Yong, Dominique

AU - Lang, Jocelyn

AU - Sivalingam, Abilash

AU - Procter, Simon R.

AU - Flasche, Stefan

AU - Waites, William

AU - Prem, Kiesha

AU - Pearson, Carl A.B.

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AU - Wong, Kerry L.M.

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AU - Mee, Paul

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AU - Munday, James D.

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AU - Davies, Nicholas G.

AU - Hodgson, David

AU - Abbas, Kaja

AU - McCarthy, Ciara V.

AU - Hellewell, Joel

AU - Abbott, Sam

AU - Bosse, Nikos I.

AU - Brady, Oliver

AU - Barnard, Rosanna C.

AU - Jit, Mark

AU - Tully, Damien C.

AU - Medley, Graham

AU - Sun, Fiona Yueqian

AU - Jarvis, Christopher I.

AU - Lowev, Rachel

AU - O’Reilly, Kathleen

AU - Meakin, Sophie R.

AU - Endo, Akira

AU - Sandmann, Frank G.

AU - Edmunds, W. John

AU - Koltai, Mihaly

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AB - The emergence of highly transmissible SARS-CoV-2 variants has created a need to reassess the risk posed by increasing social contacts as countries resume pre-pandemic activities, particularly in the context of resuming large-scale events over multiple days. To examine how social contacts formed in different activity settings influences interventions required to control Delta variant outbreaks, we collected high-resolution data on contacts among passengers and crew on cruise ships and combined the data with network transmission models. We found passengers had a median of 20 (IQR 10–36) unique close contacts per day, and over 60% of their contact episodes were made in dining or sports areas where mask wearing is typically limited. In simulated outbreaks, we found that vaccination coverage and rapid antigen tests had a larger effect than mask mandates alone, indicating the importance of combined interventions against Delta to reduce event risk in the vaccine era.

KW - Covid-19

KW - high resolution contact networks

KW - SARS-CoV-2

KW - transmission

KW - control

KW - large-scale multi-day events

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DO - 10.1038/s41467-022-29522-y

M3 - Article

C2 - 35414056

AN - SCOPUS:85128145113

SN - 2041-1723

VL - 13

JO - Nature Communications

JF - Nature Communications

IS - 1

M1 - 1956

ER -

Using high-resolution contact networks to evaluate SARS-CoV-2 transmission and control in large-scale multi-day events

Abstract

Funding

Keywords

UN SDGs

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