TY - JOUR
T1 - Using discrete multi-physics for detailed exploration of hydrodynamics in an in vitro colon system
AU - Alexiadis, A.
AU - Stamatopoulos, K.
AU - Wen, W.
AU - Batchelor, H.K.
AU - Bakalis, S.
AU - Barigou, M.
AU - Simmons, M.J.H.
PY - 2017/2/1
Y1 - 2017/2/1
N2 - We developed a mathematical model that describes the motion of viscous fluids in the partially-filled colon caused by the periodic contractions of flexible walls (peristalsis). In-vitro data are used to validate the model. The model is then used to identify two fundamental mechanisms of mass transport: the surfing mode and the pouring mode. The first mechanism is faster, but only involves the surface of the liquid. The second mechanism causes deeper mixing, and appears to be the main transport mechanism. Based on the gained understanding, we propose a series of measures that can improve the reliability of in-vitro models. The tracer in PET-like experiments, in particular, should not be injected in the first pocket, and its viscosity should be as close as possible to that of the fluid. If these conditions are not met, the dynamics of the tracer and the fluid diverge, compromising the accuracy of the in-vitro data.
AB - We developed a mathematical model that describes the motion of viscous fluids in the partially-filled colon caused by the periodic contractions of flexible walls (peristalsis). In-vitro data are used to validate the model. The model is then used to identify two fundamental mechanisms of mass transport: the surfing mode and the pouring mode. The first mechanism is faster, but only involves the surface of the liquid. The second mechanism causes deeper mixing, and appears to be the main transport mechanism. Based on the gained understanding, we propose a series of measures that can improve the reliability of in-vitro models. The tracer in PET-like experiments, in particular, should not be injected in the first pocket, and its viscosity should be as close as possible to that of the fluid. If these conditions are not met, the dynamics of the tracer and the fluid diverge, compromising the accuracy of the in-vitro data.
KW - fluid dynamics
KW - fluid-structure interaction
KW - intestine
KW - mathematical modelling
KW - peristalsis
KW - smoothed particle hydrodynamics
UR - http://www.scopus.com/inward/record.url?scp=85009152030&partnerID=8YFLogxK
U2 - 10.1016/j.compbiomed.2017.01.003
DO - 10.1016/j.compbiomed.2017.01.003
M3 - Article
C2 - 28088672
AN - SCOPUS:85009152030
SN - 0010-4825
VL - 81
SP - 188
EP - 198
JO - Computers in Biology and Medicine
JF - Computers in Biology and Medicine
ER -