Ursane-type pentacyclic triterpenoids as useful platforms in anticancer drug discovery

Jorge A. R. Salvador; Vânia M. Moreira; Bruno M. F. Goncalves; Ana S. Leal; Yongkui Jing

doi:10.1039/c2np20060k

Ursane-type pentacyclic triterpenoids as useful platforms in anticancer drug discovery

Jorge A. R. Salvador, Vânia M. Moreira, Bruno M. F. Goncalves, Ana S. Leal, Yongkui Jing

Strathclyde Institute Of Pharmacy And Biomedical Sciences

Research output: Contribution to journal › Review article › peer-review

128 Citations (Scopus)

Abstract

This review highlights the potential of natural and semisynthetic ursane-type triterpenoids as candidates for the design of multi-target bioactive compounds, with focus on their anticancer effects. A brief illustration of the biosynthesis, sources, and general biological effects of the main classes of naturally occurring pentacyclic triterpenoids (PTs) are provided.

Original language	English
Pages (from-to)	1463-1479
Number of pages	17
Journal	Natural product reports
Volume	29
Issue number	12
DOIs	https://doi.org/10.1039/c2np20060k
Publication status	Published - 9 Oct 2012

Keywords

triterpenoids
anticancer drugs
pentacyclic triterpenoids

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10.1039/c2np20060k

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title = "Ursane-type pentacyclic triterpenoids as useful platforms in anticancer drug discovery",

abstract = "This review highlights the potential of natural and semisynthetic ursane-type triterpenoids as candidates for the design of multi-target bioactive compounds, with focus on their anticancer effects. A brief illustration of the biosynthesis, sources, and general biological effects of the main classes of naturally occurring pentacyclic triterpenoids (PTs) are provided.",

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AU - Salvador, Jorge A. R.

AU - Moreira, Vânia M.

AU - Goncalves, Bruno M. F.

AU - Leal, Ana S.

AU - Jing, Yongkui

PY - 2012/10/9

Y1 - 2012/10/9

N2 - This review highlights the potential of natural and semisynthetic ursane-type triterpenoids as candidates for the design of multi-target bioactive compounds, with focus on their anticancer effects. A brief illustration of the biosynthesis, sources, and general biological effects of the main classes of naturally occurring pentacyclic triterpenoids (PTs) are provided.

AB - This review highlights the potential of natural and semisynthetic ursane-type triterpenoids as candidates for the design of multi-target bioactive compounds, with focus on their anticancer effects. A brief illustration of the biosynthesis, sources, and general biological effects of the main classes of naturally occurring pentacyclic triterpenoids (PTs) are provided.

KW - triterpenoids

KW - anticancer drugs

KW - pentacyclic triterpenoids

U2 - 10.1039/c2np20060k

DO - 10.1039/c2np20060k

M3 - Review article

SN - 0265-0568

VL - 29

SP - 1463

EP - 1479

JO - Natural product reports

JF - Natural product reports

IS - 12

ER -

Ursane-type pentacyclic triterpenoids as useful platforms in anticancer drug discovery

Abstract

Keywords

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