Ursane-type pentacyclic triterpenoids as useful platforms in anticancer drug discovery

Jorge A. R. Salvador, Vânia M. Moreira, Bruno M. F. Goncalves, Ana S. Leal, Yongkui Jing

Research output: Contribution to journalReview article

89 Citations (Scopus)

Abstract

This review highlights the potential of natural and semisynthetic ursane-type triterpenoids as candidates for the design of multi-target bioactive compounds, with focus on their anticancer effects. A brief illustration of the biosynthesis, sources, and general biological effects of the main classes of naturally occurring pentacyclic triterpenoids (PTs) are provided.
Original languageEnglish
Pages (from-to)1463-1479
Number of pages17
JournalNatural product reports
Volume29
Issue number12
DOIs
Publication statusPublished - 9 Oct 2012

Keywords

  • triterpenoids
  • anticancer drugs
  • pentacyclic triterpenoids

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