Ursane-type pentacyclic triterpenoids as useful platforms in anticancer drug discovery

Jorge A. R. Salvador, Vânia M. Moreira, Bruno M. F. Goncalves, Ana S. Leal, Yongkui Jing

Research output: Contribution to journalReview article

73 Citations (Scopus)

Abstract

This review highlights the potential of natural and semisynthetic ursane-type triterpenoids as candidates for the design of multi-target bioactive compounds, with focus on their anticancer effects. A brief illustration of the biosynthesis, sources, and general biological effects of the main classes of naturally occurring pentacyclic triterpenoids (PTs) are provided.
LanguageEnglish
Pages1463-1479
Number of pages17
JournalNatural product reports
Volume29
Issue number12
DOIs
Publication statusPublished - 9 Oct 2012

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Biosynthesis
Drug Discovery
ursane

Keywords

  • triterpenoids
  • anticancer drugs
  • pentacyclic triterpenoids

Cite this

Salvador, Jorge A. R. ; Moreira, Vânia M. ; Goncalves, Bruno M. F. ; Leal, Ana S. ; Jing, Yongkui. / Ursane-type pentacyclic triterpenoids as useful platforms in anticancer drug discovery. In: Natural product reports. 2012 ; Vol. 29, No. 12. pp. 1463-1479.
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Ursane-type pentacyclic triterpenoids as useful platforms in anticancer drug discovery. / Salvador, Jorge A. R.; Moreira, Vânia M.; Goncalves, Bruno M. F.; Leal, Ana S.; Jing, Yongkui.

In: Natural product reports, Vol. 29, No. 12, 09.10.2012, p. 1463-1479.

Research output: Contribution to journalReview article

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AU - Salvador, Jorge A. R.

AU - Moreira, Vânia M.

AU - Goncalves, Bruno M. F.

AU - Leal, Ana S.

AU - Jing, Yongkui

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AB - This review highlights the potential of natural and semisynthetic ursane-type triterpenoids as candidates for the design of multi-target bioactive compounds, with focus on their anticancer effects. A brief illustration of the biosynthesis, sources, and general biological effects of the main classes of naturally occurring pentacyclic triterpenoids (PTs) are provided.

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KW - pentacyclic triterpenoids

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JO - Natural product reports

T2 - Natural product reports

JF - Natural product reports

SN - 0265-0568

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