Projects per year
This review aims to compare both treatment strategies for resectable pancreatic cancer. PubMed, MEDLINE, Embase, Cochrane Database and Cochrane Databases were searched for studies comparing neoadjuvant and surgery-first with adjuvant therapy for resectable pancreatic cancer. A Bayesian network meta-analysis was conducted using the Markov chain Monte Carlo method. Cochrane Collaboration’s risk of bias, ROBINS-I and GRADE tools were used to assess quality and risk of bias of included trials.
9 studies compared neoadjuvant therapy and surgery-first with adjuvant therapy (n = 22,285). Aggregate rate (AR) of R0 resection for neoadjuvant therapy was 0.8008 (0.3636–0.9144) versus 0.7515 (0.2026–0.8611) odds ratio (O.R.) 1.27 (95% CI 0.60–1.96). 1-year survival AR for neoadjuvant therapy was 0.7969 (0.6061–0.9500) versus 0.7481 (0.4848–0.8500) O.R. 1.38 (95% CI 0.69–2.96). 2-year survival AR for neoadjuvant therapy was 0.5178 (0.3000–0.5970) versus 0.5131 (0.2727–0.5346) O.R. 1.26 (95% CI 0.94–1.74). 5-year AR survival for neoadjuvant therapy was 0.2069 (0.0323–0.3300) versus 0.1783 (0.0606–0.2300) O.R. 1.19 (95% CI 0.65–1.73).
In conclusion neoadjuvant therapy may offer benefit over surgery-first and adjuvant therapy. However, further randomized controlled trials are needed.
- pancreatic cancer
- neoadjuvant therapy
- Bayesian network model
Research Output per year
A prognostic Bayesian network that makes personalized predictions of poor prognostic outcome post resection of pancreatic ductal adenocarcinomaBradley, A., Van der Meer, R. & McKay, C. J., 9 Sep 2019, In : PLoS ONE. 14, 9, 14 p., e0222270.
Research output: Contribution to journal › Article
Research output: Contribution to conference › Poster
Making personalized predictions of poor outcome post resection of pancreatic ductal adenocarcinoma (PDAC): a prognostic bayesian network with pre- and post-operative applicationBradley, A., Van der Meer, R., McKay, C. & Jamieson, N., 5 Jun 2019, In : Pancreatology. 19, S1, p. S122 1 p., P6-13.
Research output: Contribution to journal › Meeting abstract