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The mechanism of the reactions between dppf-Ni0 complexes and alkyl halides has been investigated using kinetic and mechanistic experiments and DFT calculations. The active species is [Ni(κ2-dppf)(κ1-dppf)], which undergoes a halide abstraction reaction with alkyl halides and rapidly captures the alkyl radical that is formed. The rates of the reactions of [Ni(COD)(dppf)] with alkyl halides and the yields of prototypical nickel-catalyzed Kumada cross-coupling reactions of alkyl halides are shown to be significantly improved by the addition of free dppf ligand.
- homogenous catalysis
- cross coupling
- reaction mechanisms
- organometallic chemistry
1/10/17 → 1/10/21
Project: Research Studentship Case - Internally allocated
Data for: "Unexpected Nickel Complex Speciation Unlocks Alternative Pathways for the Reactions of Alkyl Halides with dppf-Nickel(0)"
The effect of added ligands on the reactions of [Ni(COD)(dppf)] with alkyl halides: halide abstraction may be reversibleGreaves, M. E., Ronson, T. O., Maseras, F. & Nelson, D. J., 3 Jun 2021, (Accepted/In press) In: Organometallics.
Research output: Contribution to journal › Article › peer-review