Projects per year
Abstract
The mechanism of the reactions between dppf-Ni0 complexes and alkyl halides has been investigated using kinetic and mechanistic experiments and DFT calculations. The active species is [Ni(κ2-dppf)(κ1-dppf)], which undergoes a halide abstraction reaction with alkyl halides and rapidly captures the alkyl radical that is formed. The rates of the reactions of [Ni(COD)(dppf)] with alkyl halides and the yields of prototypical nickel-catalyzed Kumada cross-coupling reactions of alkyl halides are shown to be significantly improved by the addition of free dppf ligand.
Original language | English |
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Pages (from-to) | 10717-10725 |
Number of pages | 9 |
Journal | ACS Catalysis |
Volume | 10 |
Issue number | 18 |
Early online date | 21 Aug 2020 |
DOIs | |
Publication status | Published - 18 Sept 2020 |
Keywords
- nickel
- homogenous catalysis
- cross coupling
- reaction mechanisms
- organometallic chemistry
Fingerprint
Dive into the research topics of 'Unexpected nickel complex speciation unlocks alternative pathways for the reactions of alkyl halides with dppf-nickel(0)'. Together they form a unique fingerprint.Profiles
Projects
- 2 Finished
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AstraZeneca ICASE
Nelson, D. (Principal Investigator)
1/10/17 → 30/09/21
Project: Research - Studentship
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Industrial CASE Account - University of Strathclyde 2017 | Greaves, Megan
Nelson, D. (Principal Investigator), Murphy, J. (Co-investigator) & Greaves, M. (Research Co-investigator)
EPSRC (Engineering and Physical Sciences Research Council)
1/10/17 → 14/09/21
Project: Research Studentship Case - Internally allocated
Datasets
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Data for: "Unexpected Nickel Complex Speciation Unlocks Alternative Pathways for the Reactions of Alkyl Halides with dppf-Nickel(0)"
Nelson, D. (Creator) & Greaves, M. (Creator), University of Strathclyde, 27 Aug 2020
DOI: 10.15129/7ec1bd50-bdaf-4225-b300-10f875f1f4ae
Dataset
Research output
- 21 Citations
- 1 Article
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The effect of added ligands on the reactions of [Ni(COD)(dppf)] with alkyl halides: halide abstraction may be reversible
Greaves, M. E., Ronson, T. O., Maseras, F. & Nelson, D. J., 16 Jun 2021, In: Organometallics. 40, 12, p. 1997-2007 11 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile10 Citations (Scopus)46 Downloads (Pure)
Activities
- 1 Oral presentation
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Reaction Mechanisms and Structure/ Reactivity Relationships in Nickel-Catalysed Cross-Coupling Reactions
Nelson, D. (Speaker)
26 Jun 2019Activity: Talk or presentation types › Oral presentation