Understanding the compaction behaviour of low-substituted HPC: macro, micro, and nano-metric evaluations

Amr ElShaer, Ali Al-khattawi, Afzal R. Mohammed, Monika Warzecha, Dimitrios A. Lamprou, Hany Hassanin

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

The fast development in materials science has resulted in the emergence of new pharmaceutical materials with superior physical and mechanical properties. Low-substituted hydroxypropyl cellulose is an ether derivative of cellulose and is praised for its multi-functionality as a binder, disintegrant, film coating agent and as a suitable material for medical dressings. Nevertheless, very little is known about the compaction behaviour of this polymer. The aim of the current study was to evaluate the compaction and disintegration behaviour of four grades of L-HPC namely; LH32, LH21, LH11, and LHB1. The macrometric properties of the four powders were studied and the compaction behaviour was evaluated using the out-of-die method. LH11 and LH22 showed poor flow properties as the powders were dominated by fibrous particles with high aspect ratios, which reduced the powder flow. LH32 showed a weak compressibility profile and demonstrated a large elastic region, making it harder for this polymer to deform plastically. These findings are supported by AFM which revealed the high roughness of LH32 powder (100.09 ± 18.84 nm), resulting in small area of contact, but promoting mechanical interlocking. On the contrary, LH21 and LH11 powders had smooth surfaces which enabled larger contact area and higher adhesion forces of 21.01 ± 11.35 nN and 9.50 ± 5.78 nN, respectively. This promoted bond formation during compression as LH21 and LH11 powders had low strength yield.

LanguageEnglish
Number of pages12
JournalPharmaceutical Development and Technology
Early online date18 Aug 2017
DOIs
Publication statusE-pub ahead of print - 18 Aug 2017

Fingerprint

Powders
Polymers
Bandages
Cellulose
Pharmaceutical Preparations

Keywords

  • AFM
  • BET
  • compaction
  • disintegration time
  • L-HPC
  • porosity
  • atomic force microscopy

Cite this

ElShaer, Amr ; Al-khattawi, Ali ; Mohammed, Afzal R. ; Warzecha, Monika ; Lamprou, Dimitrios A. ; Hassanin, Hany. / Understanding the compaction behaviour of low-substituted HPC : macro, micro, and nano-metric evaluations. In: Pharmaceutical Development and Technology. 2017.
@article{ccbd66d6383b4c2bb91cfad9b77985c3,
title = "Understanding the compaction behaviour of low-substituted HPC: macro, micro, and nano-metric evaluations",
abstract = "The fast development in materials science has resulted in the emergence of new pharmaceutical materials with superior physical and mechanical properties. Low-substituted hydroxypropyl cellulose is an ether derivative of cellulose and is praised for its multi-functionality as a binder, disintegrant, film coating agent and as a suitable material for medical dressings. Nevertheless, very little is known about the compaction behaviour of this polymer. The aim of the current study was to evaluate the compaction and disintegration behaviour of four grades of L-HPC namely; LH32, LH21, LH11, and LHB1. The macrometric properties of the four powders were studied and the compaction behaviour was evaluated using the out-of-die method. LH11 and LH22 showed poor flow properties as the powders were dominated by fibrous particles with high aspect ratios, which reduced the powder flow. LH32 showed a weak compressibility profile and demonstrated a large elastic region, making it harder for this polymer to deform plastically. These findings are supported by AFM which revealed the high roughness of LH32 powder (100.09 ± 18.84 nm), resulting in small area of contact, but promoting mechanical interlocking. On the contrary, LH21 and LH11 powders had smooth surfaces which enabled larger contact area and higher adhesion forces of 21.01 ± 11.35 nN and 9.50 ± 5.78 nN, respectively. This promoted bond formation during compression as LH21 and LH11 powders had low strength yield.",
keywords = "AFM, BET, compaction, disintegration time, L-HPC, porosity, atomic force microscopy",
author = "Amr ElShaer and Ali Al-khattawi and Mohammed, {Afzal R.} and Monika Warzecha and Lamprou, {Dimitrios A.} and Hany Hassanin",
year = "2017",
month = "8",
day = "18",
doi = "10.1080/10837450.2017.1363775",
language = "English",
journal = "Pharmaceutical Development and Technology",
issn = "1083-7450",

}

Understanding the compaction behaviour of low-substituted HPC : macro, micro, and nano-metric evaluations. / ElShaer, Amr; Al-khattawi, Ali; Mohammed, Afzal R.; Warzecha, Monika; Lamprou, Dimitrios A.; Hassanin, Hany.

In: Pharmaceutical Development and Technology, 18.08.2017.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Understanding the compaction behaviour of low-substituted HPC

T2 - Pharmaceutical Development and Technology

AU - ElShaer, Amr

AU - Al-khattawi, Ali

AU - Mohammed, Afzal R.

AU - Warzecha, Monika

AU - Lamprou, Dimitrios A.

AU - Hassanin, Hany

PY - 2017/8/18

Y1 - 2017/8/18

N2 - The fast development in materials science has resulted in the emergence of new pharmaceutical materials with superior physical and mechanical properties. Low-substituted hydroxypropyl cellulose is an ether derivative of cellulose and is praised for its multi-functionality as a binder, disintegrant, film coating agent and as a suitable material for medical dressings. Nevertheless, very little is known about the compaction behaviour of this polymer. The aim of the current study was to evaluate the compaction and disintegration behaviour of four grades of L-HPC namely; LH32, LH21, LH11, and LHB1. The macrometric properties of the four powders were studied and the compaction behaviour was evaluated using the out-of-die method. LH11 and LH22 showed poor flow properties as the powders were dominated by fibrous particles with high aspect ratios, which reduced the powder flow. LH32 showed a weak compressibility profile and demonstrated a large elastic region, making it harder for this polymer to deform plastically. These findings are supported by AFM which revealed the high roughness of LH32 powder (100.09 ± 18.84 nm), resulting in small area of contact, but promoting mechanical interlocking. On the contrary, LH21 and LH11 powders had smooth surfaces which enabled larger contact area and higher adhesion forces of 21.01 ± 11.35 nN and 9.50 ± 5.78 nN, respectively. This promoted bond formation during compression as LH21 and LH11 powders had low strength yield.

AB - The fast development in materials science has resulted in the emergence of new pharmaceutical materials with superior physical and mechanical properties. Low-substituted hydroxypropyl cellulose is an ether derivative of cellulose and is praised for its multi-functionality as a binder, disintegrant, film coating agent and as a suitable material for medical dressings. Nevertheless, very little is known about the compaction behaviour of this polymer. The aim of the current study was to evaluate the compaction and disintegration behaviour of four grades of L-HPC namely; LH32, LH21, LH11, and LHB1. The macrometric properties of the four powders were studied and the compaction behaviour was evaluated using the out-of-die method. LH11 and LH22 showed poor flow properties as the powders were dominated by fibrous particles with high aspect ratios, which reduced the powder flow. LH32 showed a weak compressibility profile and demonstrated a large elastic region, making it harder for this polymer to deform plastically. These findings are supported by AFM which revealed the high roughness of LH32 powder (100.09 ± 18.84 nm), resulting in small area of contact, but promoting mechanical interlocking. On the contrary, LH21 and LH11 powders had smooth surfaces which enabled larger contact area and higher adhesion forces of 21.01 ± 11.35 nN and 9.50 ± 5.78 nN, respectively. This promoted bond formation during compression as LH21 and LH11 powders had low strength yield.

KW - AFM

KW - BET

KW - compaction

KW - disintegration time

KW - L-HPC

KW - porosity

KW - atomic force microscopy

UR - http://www.scopus.com/inward/record.url?scp=85027876360&partnerID=8YFLogxK

U2 - 10.1080/10837450.2017.1363775

DO - 10.1080/10837450.2017.1363775

M3 - Article

JO - Pharmaceutical Development and Technology

JF - Pharmaceutical Development and Technology

SN - 1083-7450

ER -