Understanding protein corona formation under shear flow conditions

Karim Daramy; Yvonne Perrie; Zahra Rattray

Understanding protein corona formation under shear flow conditions

Karim Daramy, Yvonne Perrie, Zahra Rattray

Strathclyde Institute Of Pharmacy And Biomedical Sciences

Research output: Contribution to conference › Poster

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Abstract

Nanoparticles are small colloidal particles in the 1-100 nm size range. Polymeric nanoparticles are routinely explored for the development of novel drug delivery systems due to their unique and customizable physical and chemical characteristics. Upon introduction to protein-containing medium, nanoparticles will spontaneously adsorb proteins onto their surface and form what is known as the ‘protein corona’. The protein corona leads to changes in the physical and chemical parameters of nanoparticles, which subsequently alters their biological fate (cellular uptake, biodistribution). With most
nanoparticles intended for intravenous administration, it is crucial to understand the impact of biological shear flow conditions on protein corona formation and how the protein corona influences their colloidal stability.

Original language	English
Publication status	Published - 22 Nov 2022
Event	JPAG Pharmaceutical Analysis Research Awards and Careers Fair 2022 - RSC, London, United Kingdom Duration: 22 Nov 2022 → 22 Nov 2022 https://www.jpag.org/

Conference

Conference	JPAG Pharmaceutical Analysis Research Awards and Careers Fair 2022
Country/Territory	United Kingdom
City	London
Period	22/11/22 → 22/11/22
Internet address	https://www.jpag.org/

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being
SDG 9 Industry, Innovation, and Infrastructure

Keywords

nanomedicine
nanoparticles
polystyrene latex nanoparticle parameters

Access to Document

Daramy-etal-JPAG-2022-Understanding-protein-corona-formation-under-shear-flow-conditionsFinal published version, 1.4 MBLicence: Strath_1

Multiscale Metrology Suite for Next-generation Healthcare Technologies (EPSRC Strategic Equipment)
Rattray, Z. (Principal Investigator), Bruns, N. (Co-investigator), Faulds, K. (Co-investigator), Graham, D. (Co-investigator), Halbert, G. (Co-investigator), Hoskins, C. (Co-investigator), McArthur, S. (Co-investigator), Perrie, Y. (Co-investigator), Reid, S. (Co-investigator) & Seib, P. (Co-investigator)
EPSRC (Engineering and Physical Sciences Research Council)
1/11/21 → 31/10/24
Project: Research
Doctoral Training Partnership 2018-19 University of Strathclyde | Daramy, Karim
Rattray, Z. (Principal Investigator), Perrie, Y. (Co-investigator) & Daramy, K. (Research Co-investigator)
EPSRC (Engineering and Physical Sciences Research Council)
1/10/20 → 19/09/24
Project: Research Studentship - Internally Allocated

Cite this

@conference{391758998e504b3f8540d1b709322c09,

title = "Understanding protein corona formation under shear flow conditions",

abstract = "Nanoparticles are small colloidal particles in the 1-100 nm size range. Polymeric nanoparticles are routinely explored for the development of novel drug delivery systems due to their unique and customizable physical and chemical characteristics. Upon introduction to protein-containing medium, nanoparticles will spontaneously adsorb proteins onto their surface and form what is known as the {\textquoteleft}protein corona{\textquoteright}. The protein corona leads to changes in the physical and chemical parameters of nanoparticles, which subsequently alters their biological fate (cellular uptake, biodistribution). With most nanoparticles intended for intravenous administration, it is crucial to understand the impact of biological shear flow conditions on protein corona formation and how the protein corona influences their colloidal stability.",

keywords = "nanomedicine, nanoparticles, polystyrene latex nanoparticle parameters",

author = "Karim Daramy and Yvonne Perrie and Zahra Rattray",

year = "2022",

month = nov,

day = "22",

language = "English",

note = "JPAG Pharmaceutical Analysis Research Awards and Careers Fair 2022 ; Conference date: 22-11-2022 Through 22-11-2022",

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TY - CONF

T1 - Understanding protein corona formation under shear flow conditions

AU - Daramy, Karim

AU - Perrie, Yvonne

AU - Rattray, Zahra

PY - 2022/11/22

Y1 - 2022/11/22

N2 - Nanoparticles are small colloidal particles in the 1-100 nm size range. Polymeric nanoparticles are routinely explored for the development of novel drug delivery systems due to their unique and customizable physical and chemical characteristics. Upon introduction to protein-containing medium, nanoparticles will spontaneously adsorb proteins onto their surface and form what is known as the ‘protein corona’. The protein corona leads to changes in the physical and chemical parameters of nanoparticles, which subsequently alters their biological fate (cellular uptake, biodistribution). With most nanoparticles intended for intravenous administration, it is crucial to understand the impact of biological shear flow conditions on protein corona formation and how the protein corona influences their colloidal stability.

AB - Nanoparticles are small colloidal particles in the 1-100 nm size range. Polymeric nanoparticles are routinely explored for the development of novel drug delivery systems due to their unique and customizable physical and chemical characteristics. Upon introduction to protein-containing medium, nanoparticles will spontaneously adsorb proteins onto their surface and form what is known as the ‘protein corona’. The protein corona leads to changes in the physical and chemical parameters of nanoparticles, which subsequently alters their biological fate (cellular uptake, biodistribution). With most nanoparticles intended for intravenous administration, it is crucial to understand the impact of biological shear flow conditions on protein corona formation and how the protein corona influences their colloidal stability.

KW - nanomedicine

KW - nanoparticles

KW - polystyrene latex nanoparticle parameters

M3 - Poster

T2 - JPAG Pharmaceutical Analysis Research Awards and Careers Fair 2022

Y2 - 22 November 2022 through 22 November 2022

ER -

Understanding protein corona formation under shear flow conditions

Abstract

Conference

UN SDGs

Keywords

Access to Document

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Projects

Multiscale Metrology Suite for Next-generation Healthcare Technologies (EPSRC Strategic Equipment)

Doctoral Training Partnership 2018-19 University of Strathclyde | Daramy, Karim

Cite this