Understanding protein corona formation under shear flow conditions

Research output: Contribution to conferencePoster

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Abstract

Nanoparticles are small colloidal particles in the 1-100 nm size range. Polymeric nanoparticles are routinely explored for the development of novel drug delivery systems due to their unique and customizable physical and chemical characteristics. Upon introduction to protein-containing medium, nanoparticles will spontaneously adsorb proteins onto their surface and form what is known as the ‘protein corona’. The protein corona leads to changes in the physical and chemical parameters of nanoparticles, which subsequently alters their biological fate (cellular uptake, biodistribution). With most
nanoparticles intended for intravenous administration, it is crucial to understand the impact of biological shear flow conditions on protein corona formation and how the protein corona influences their colloidal stability.
Original languageEnglish
Publication statusPublished - 22 Nov 2022
EventJPAG Pharmaceutical Analysis Research Awards and Careers Fair 2022 - RSC, London, United Kingdom
Duration: 22 Nov 202222 Nov 2022
https://www.jpag.org/

Conference

ConferenceJPAG Pharmaceutical Analysis Research Awards and Careers Fair 2022
Country/TerritoryUnited Kingdom
CityLondon
Period22/11/2222/11/22
Internet address

Keywords

  • nanomedicine
  • nanoparticles
  • polystyrene latex nanoparticle parameters

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