Projects per year
Developing a continuous isolation process to produce a pure, dry, free-flowing active pharmaceutical ingredient (API) is the final barrier to the implementation of continuous end-to-end pharmaceutical manufacturing. Recent work has led to the development of continuous filtration and washing prototypes for pharmaceutical process development and small-scale manufacture. Here, we address the challenge of static drying of a solvent-wet crystalline API in a fixed bed to facilitate the design of a continuous filter dryer for pharmaceutical development, without excessive particle breakage or the formation of interparticle bridges leading to lump formation. We demonstrate the feasibility of drying small batches on a time scale suitable for continuous manufacturing, complemented by the development of a drying model that provides a design tool for process development. We also evaluate the impact of alternative washing and drying approaches on particle agglomeration. We conclude that our approach yields effective technology, with a performance that is amenable to predictive modeling.
- model validation
28/04/14 → 30/08/19
Project: Research Fellowship
Data for: "Understanding API static drying with hot gas flow: design and test of a drying rig prototype and drying modelling development"
Ottoboni, S. (Creator), Coleman, S. (Contributor), Steven, C. R. (Contributor), Siddique, M. (Contributor), Price, C. J. (Contributor) & Mulheran, P. (Contributor), University of Strathclyde, 30 Sep 2020