Ultrasound assisted particle and cell manipulation on-chip

Helen Mulvana, Sandy Cochran, Martyn Hill

Research output: Contribution to journalArticle

44 Citations (Scopus)

Abstract

Ultrasonic fields are able to exert forces on cells and other micron-scale particles, including microbubbles. The technology is compatible with existing lab-on-chip techniques and is complementary to many alternative manipulation approaches due to its ability to handle many cells simultaneously over extended length scales. This paper provides an overview of the physical principles underlying ultrasonic manipulation, discusses the biological effects relevant to its use with cells, and describes emerging applications that are of interest in the field of drug development and delivery on-chip.
Original languageEnglish
Pages (from-to)1600-1610
Number of pages11
JournalAdvanced Drug Delivery Reviews
Volume65
Issue number11-12
Early online date29 Jul 2013
DOIs
Publication statusPublished - 15 Nov 2013

Keywords

  • ultra sound
  • ultrasonic fields
  • particle manipulation
  • cell manipulation
  • microbubbles

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