Ultrasonic monitoring of artificial tissue mechanical properties in biorreactor

Guillermo Rus, Nicolas Bochud, Juan Melchor, Laura Peralta, Juan Chiachio, Manuel Chiachio, Antonio Gomez, Juan Antonio Marchal

Research output: Contribution to conferenceProceedingpeer-review


Quantitative control of tissue processes in bioreactors is an open problem in tissue engineering, aimed at creating artificial tissues and organs. To standardize and optimize the process, it is necessary to control most of the parameters that may vary its effectiveness. We propose to monitor the changes that may suffer the matrix during the process using mechanical parameters. To ensure the viability of this protocol, a bioreactor has been designed. The proposed methodology consists of three elements: an (1) experimental setup based on ultrasound-tissue interactions monitored in real-time, a (2) computational model that simulates the ultrasound-tissue interactions, and a (3) model-based inverse problem to reconstruct the evolution of the mechanical parameters
Original languageEnglish
Number of pages7
Publication statusPublished - 2014
EventInternational Work-Conference on Bioinformatics and Biomedical Engineering - Granada, Spain
Duration: 1 Jul 2014 → …


ConferenceInternational Work-Conference on Bioinformatics and Biomedical Engineering
Abbreviated title IWBBIO 2014
Period1/07/14 → …


  • ultrasonic monitoring
  • artificial tissue
  • mechanical parameters
  • bioreactor
  • ultrasound-tissue interactions

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