Ultrasensitive detection of ribonucleic acid biomarkers using portable sensing platforms based on organic electrochemical transistors

Ying Fu, Naixiang Wang, Anneng Yang, Zhiai Xu, Wen Zhang, Hong Liu, Helen Ka-wai Law, Feng Yan

Research output: Contribution to journalArticlepeer-review

Abstract

The analysis of ribonucleic acid (RNA) plays an important role in the early diagnosis of diseases and will greatly benefit patients with a higher cure rate. However, the low abundance of RNA in physiological environments requires ultrahigh sensitivity of a detection technology. Here, we construct a portable and smart-phone-controlled biosensing platform based on disposable organic electrochemical transistors for ultrasensitive analysis of microRNA (miRNA) biomarkers within 1 h. Due to their inherent amplification function, the devices can detect miRNA cancer biomarkers from little-volume solutions with concentrations down to 10–14 M. The devices can distinguish blood miRNA expression levels at different cancer stages using a 4T1 mouse tumor model. The technique for ultrasensitive and fast detection of RNA biomarkers with high selectivity opens a window for mobile diagnosis of various diseases with low cost.
Original languageEnglish
Pages (from-to)14359-14364
Number of pages6
JournalAnalytical Chemistry
Volume93
Issue number43
Early online date18 Oct 2021
DOIs
Publication statusPublished - 2 Nov 2021

Keywords

  • ribonulceic acid (RNA)
  • biomarkers
  • portable sensing platforms
  • organic electrochemical transistors

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