TY - JOUR
T1 - Two new paracetamol / dioxane solvates - a system exhibiting a reversible solid state phase transformation
AU - Vrcelj, R.M.
AU - Clark, Nathan I.B.
AU - Kennedy, A.R.
AU - Sheen, D.B.
AU - Shepherd, E.E.A.
AU - Sherwood, J.N.
PY - 2003/7/29
Y1 - 2003/7/29
N2 - This work reports on the crystal structures of two dioxane solvates of paracetamol that are true polymorphs. The high temperature phase is an orthorhombic form, space group Pbca, Z = 8, a = 12.6078(3) î.., b = 12.1129(2) î.., c = 13.4138(3) î.., V = 2048.52(7) î..3, (at 295 K) and the low temperature form is monoclinic, space group P21/c, Z = 4, a = 12.325(6) î.., b = 11.965(4) î.., c = 13.384(6) î.., = 92.01°, V = 1972.6(14)î..3 (at 123 K). The structures of these polymorphs are described as is the interrelationship between the two structures. In addition to the structural interrelationship, it is shown that the two forms undergo a reversible phase transformation. Desolvation of either form generates the stable monoclinic phase of paracetamol.
AB - This work reports on the crystal structures of two dioxane solvates of paracetamol that are true polymorphs. The high temperature phase is an orthorhombic form, space group Pbca, Z = 8, a = 12.6078(3) î.., b = 12.1129(2) î.., c = 13.4138(3) î.., V = 2048.52(7) î..3, (at 295 K) and the low temperature form is monoclinic, space group P21/c, Z = 4, a = 12.325(6) î.., b = 11.965(4) î.., c = 13.384(6) î.., = 92.01°, V = 1972.6(14)î..3 (at 123 K). The structures of these polymorphs are described as is the interrelationship between the two structures. In addition to the structural interrelationship, it is shown that the two forms undergo a reversible phase transformation. Desolvation of either form generates the stable monoclinic phase of paracetamol.
KW - crystallization
KW - crystallography
KW - polymorphism
KW - solvate
UR - http://dx.doi.org/10.1002/jps.10477
U2 - 10.1002/jps.10477
DO - 10.1002/jps.10477
M3 - Article
SN - 0022-3549
VL - 92
SP - 2069
EP - 2073
JO - Journal of Pharmaceutical Sciences
JF - Journal of Pharmaceutical Sciences
IS - 10
ER -