Two new antioxidant actinosporin analogues from the calcium alginate beads culture of sponge-associated Actinokineospora sp. strain EG49

Tanja Grkovic; Usama Ramada Abdelmohsen; Eman Maher  Othman; Helga  Stopper; Ruangelie Edrada-Ebel; Ute Hentschel; Ronald Quinn

doi:10.1016/j.bmcl.2014.08.068

Two new antioxidant actinosporin analogues from the calcium alginate beads culture of sponge-associated Actinokineospora sp. strain EG49

Tanja Grkovic, Usama Ramada Abdelmohsen, Eman Maher Othman, Helga Stopper, Ruangelie Edrada-Ebel, Ute Hentschel, Ronald Quinn

Strathclyde Institute Of Pharmacy And Biomedical Sciences

Research output: Contribution to journal › Article › peer-review

38 Citations (Scopus)

Abstract

Marine sponge-associated actinomycetes represent an exciting new resource for the identification of new and novel natural products . Previously, we have reported the isolation and structural elucidation of actinosporins A (1) and B (2) from Actinokineospora sp. strain EG49 isolated from the marine sponge Spheciospongia vagabunda. Herein, by employing different fermentation conditions on the same microorganism, we report on the isolation and antioxidant activity of structurally related metabolites, actinosporins C (3) and D (4). The antioxidant potential of actinosporins C and D was demonstrated using the ferric reducing antioxidant power (FRAP) assay. Additionally, at 1.25 μM, actinosporins C and D showed a significant antioxidant and protective capacity from the genomic damage induced by hydrogen peroxide in the human promyelocytic (HL-60) cell line.

Original language	English
Pages (from-to)	5089-5092
Number of pages	4
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	24
Issue number	21
Early online date	6 Sept 2014
DOIs	https://doi.org/10.1016/j.bmcl.2014.08.068
Publication status	Published - 1 Nov 2014

Keywords

sponges
actinomycetes
actinokineospora
actinosporins
antioxidant

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.bmcl.2014.08.068

38 Citations
1 Conference Contribution

Metabolomic strategies in dereplication for targeted cultivation and isolation of new bioactive secondary metabolites from fungal endophytes and marine microbial symbionts
Cheng, C., Abdelmohsen, U. R., Grkovic, T., Quinn, R., Hentschel, U. & Edrada-Ebel, R., Aug 2013, In: Planta Medica. 79, 13, 1 p., SL29.
Research output: Contribution to journal › Conference Contribution › peer-review

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title = "Two new antioxidant actinosporin analogues from the calcium alginate beads culture of sponge-associated Actinokineospora sp. strain EG49",

abstract = "Marine sponge-associated actinomycetes represent an exciting new resource for the identification of new and novel natural products . Previously, we have reported the isolation and structural elucidation of actinosporins A (1) and B (2) from Actinokineospora sp. strain EG49 isolated from the marine sponge Spheciospongia vagabunda. Herein, by employing different fermentation conditions on the same microorganism, we report on the isolation and antioxidant activity of structurally related metabolites, actinosporins C (3) and D (4). The antioxidant potential of actinosporins C and D was demonstrated using the ferric reducing antioxidant power (FRAP) assay. Additionally, at 1.25 μM, actinosporins C and D showed a significant antioxidant and protective capacity from the genomic damage induced by hydrogen peroxide in the human promyelocytic (HL-60) cell line.",

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AU - Grkovic, Tanja

AU - Abdelmohsen, Usama Ramada

AU - Othman, Eman Maher

AU - Stopper, Helga

AU - Edrada-Ebel, Ruangelie

AU - Hentschel, Ute

AU - Quinn, Ronald

PY - 2014/11/1

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AB - Marine sponge-associated actinomycetes represent an exciting new resource for the identification of new and novel natural products . Previously, we have reported the isolation and structural elucidation of actinosporins A (1) and B (2) from Actinokineospora sp. strain EG49 isolated from the marine sponge Spheciospongia vagabunda. Herein, by employing different fermentation conditions on the same microorganism, we report on the isolation and antioxidant activity of structurally related metabolites, actinosporins C (3) and D (4). The antioxidant potential of actinosporins C and D was demonstrated using the ferric reducing antioxidant power (FRAP) assay. Additionally, at 1.25 μM, actinosporins C and D showed a significant antioxidant and protective capacity from the genomic damage induced by hydrogen peroxide in the human promyelocytic (HL-60) cell line.

KW - sponges

KW - actinomycetes

KW - actinokineospora

KW - actinosporins

KW - antioxidant

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DO - 10.1016/j.bmcl.2014.08.068

M3 - Article

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JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 21

ER -

Two new antioxidant actinosporin analogues from the calcium alginate beads culture of sponge-associated Actinokineospora sp. strain EG49

Abstract

Keywords

UN SDGs

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Research output

Metabolomic strategies in dereplication for targeted cultivation and isolation of new bioactive secondary metabolites from fungal endophytes and marine microbial symbionts

Cite this