Abstract
Ultrafast two-dimensional infrared (2D-IR) spectroscopy has provided valuable insights into biomolecular structure and dynamics, but recent progress in laser technology and data analysis methods have demonstrated the potential for high throughput 2D-IR measurements and analytical applications. Using 2D-IR as an analytical tool requires a different approach to data collection and analysis compared to pure research applications however and, in this review, we highlight progress towards usage of 2D-IR spectroscopy in areas relevant to biomedical, pharmaceutical and analytical molecular science. We summarise the technical and methodological advances made to date and discuss the challenges that still face 2D-IR spectroscopy as it attempts to transition from the state-of-the-art laser laboratory to the standard suite of analytical tools.
Original language | English |
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Pages (from-to) | 2014-2024 |
Number of pages | 11 |
Journal | Analyst |
Volume | 145 |
Issue number | 6 |
Early online date | 10 Feb 2020 |
DOIs | |
Publication status | Published - 21 Mar 2020 |
Keywords
- ultrafast 2D-IR spectroscopy
- infrared spectroscopy
- vibrational dynamics
- analytical tools