Tuned methods for conjugate addition to a vinyl oxadiazole; synthesis of pharmaceutically important motifs

Alan R. Burns, Jennifer H. Kerr, William J. Kerr, Joanna Passmore, Laura C. Paterson, Allan J. B. Watson

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Abstract

The addition of various nucleophiles to a vinyl 1,2,4-oxadiazole is described. Following optimisation, individual protocols tuned for the use of each specific class of reagent have been developed to allow the installation of nitrogen, sulfur, oxygen, and carbon nucleophiles, and leading to the preparation of a series of compounds containing the pharmaceutically important oxadiazole motif.
Original languageEnglish
Pages (from-to)2777-2783
Number of pages7
JournalOrganic and Biomolecular Chemistry
Volume8
Issue number12
Early online date28 Apr 2010
DOIs
Publication statusPublished - 2010

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Keywords

  • tuned methods
  • organic chemistry
  • vinyl oxadiazole
  • synthesis
  • pharmacology

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