Tuned methods for conjugate addition to a vinyl oxadiazole; synthesis of pharmaceutically important motifs

Alan R. Burns; Jennifer H. Kerr; William J. Kerr; Joanna Passmore; Laura C. Paterson; Allan J. B. Watson

doi:10.1039/c001772h

Tuned methods for conjugate addition to a vinyl oxadiazole; synthesis of pharmaceutically important motifs

Alan R. Burns, Jennifer H. Kerr, William J. Kerr, Joanna Passmore, Laura C. Paterson, Allan J. B. Watson

Pure And Applied Chemistry

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Abstract

The addition of various nucleophiles to a vinyl 1,2,4-oxadiazole is described. Following optimisation, individual protocols tuned for the use of each specific class of reagent have been developed to allow the installation of nitrogen, sulfur, oxygen, and carbon nucleophiles, and leading to the preparation of a series of compounds containing the pharmaceutically important oxadiazole motif.

Original language	English
Pages (from-to)	2777-2783
Number of pages	7
Journal	Organic and Biomolecular Chemistry
Volume	8
Issue number	12
Early online date	28 Apr 2010
DOIs	https://doi.org/10.1039/c001772h
Publication status	Published - 2010

Keywords

tuned methods
organic chemistry
vinyl oxadiazole
synthesis
pharmacology

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10.1039/c001772h

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abstract = "The addition of various nucleophiles to a vinyl 1,2,4-oxadiazole is described. Following optimisation, individual protocols tuned for the use of each specific class of reagent have been developed to allow the installation of nitrogen, sulfur, oxygen, and carbon nucleophiles, and leading to the preparation of a series of compounds containing the pharmaceutically important oxadiazole motif.",

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AU - Passmore, Joanna

AU - Paterson, Laura C.

AU - Watson, Allan J. B.

PY - 2010

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AB - The addition of various nucleophiles to a vinyl 1,2,4-oxadiazole is described. Following optimisation, individual protocols tuned for the use of each specific class of reagent have been developed to allow the installation of nitrogen, sulfur, oxygen, and carbon nucleophiles, and leading to the preparation of a series of compounds containing the pharmaceutically important oxadiazole motif.

KW - tuned methods

KW - organic chemistry

KW - vinyl oxadiazole

KW - synthesis

KW - pharmacology

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U2 - 10.1039/c001772h

DO - 10.1039/c001772h

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ER -

Tuned methods for conjugate addition to a vinyl oxadiazole; synthesis of pharmaceutically important motifs

Abstract

Keywords

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