Tuned methods for conjugate addition to a vinyl oxadiazole; synthesis of pharmaceutically important motifs

Alan R. Burns, Jennifer H. Kerr, William J. Kerr, Joanna Passmore, Laura C. Paterson, Allan J. B. Watson

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

The addition of various nucleophiles to a vinyl 1,2,4-oxadiazole is described. Following optimisation, individual protocols tuned for the use of each specific class of reagent have been developed to allow the installation of nitrogen, sulfur, oxygen, and carbon nucleophiles, and leading to the preparation of a series of compounds containing the pharmaceutically important oxadiazole motif.
LanguageEnglish
Pages2777-2783
Number of pages7
JournalOrganic and Biomolecular Chemistry
Volume8
Issue number12
Early online date28 Apr 2010
DOIs
Publication statusPublished - 2010

Fingerprint

Oxadiazoles
Nucleophiles
nucleophiles
synthesis
Sulfur
reagents
Nitrogen
sulfur
Carbon
Oxygen
nitrogen
preparation
optimization
carbon
oxygen

Keywords

  • tuned methods
  • organic chemistry
  • vinyl oxadiazole
  • synthesis
  • pharmacology

Cite this

Burns, Alan R. ; Kerr, Jennifer H. ; Kerr, William J. ; Passmore, Joanna ; Paterson, Laura C. ; Watson, Allan J. B. / Tuned methods for conjugate addition to a vinyl oxadiazole; synthesis of pharmaceutically important motifs. In: Organic and Biomolecular Chemistry. 2010 ; Vol. 8, No. 12. pp. 2777-2783.
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Tuned methods for conjugate addition to a vinyl oxadiazole; synthesis of pharmaceutically important motifs. / Burns, Alan R.; Kerr, Jennifer H.; Kerr, William J.; Passmore, Joanna; Paterson, Laura C.; Watson, Allan J. B.

In: Organic and Biomolecular Chemistry, Vol. 8, No. 12, 2010, p. 2777-2783.

Research output: Contribution to journalArticle

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AU - Watson, Allan J. B.

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