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The conjugation of lactoferrin and lactoferricin to the dendrimer significantly increased the gene expression in the tumor while decreasing the non-specific gene expression in the liver. Consequently, the intravenous administration of the targeted dendriplexes encoding TNFα led to the complete suppression of 60% of A431 tumors and up to 50% of B16-F10 tumors over one month. The treatment was well tolerated by the animals. These results suggest that these novel lactoferrin- and lactoferricin-bearing dendrimers are promising gene delivery systems for cancer therapy.
|Number of pages||10|
|Journal||Nanomedicine: Nanotechnology, Biology and Medicine|
|Early online date||29 Apr 2015|
|Publication status||Published - 31 Aug 2015|
- cancer therapy
- gene delivery