Tryptase as a PAR-2 activator in joint inflammation

E.B. Kelso; L. Dunning; J.C. Lockhart; W.R. Ferrell; R. Plevin; C.P. Sommerhoff

doi:10.1186/ar1620

Tryptase as a PAR-2 activator in joint inflammation

E.B. Kelso, L. Dunning, J.C. Lockhart, W.R. Ferrell, R. Plevin, C.P. Sommerhoff

Strathclyde Institute Of Pharmacy And Biomedical Sciences

Research output: Contribution to conference › Poster

Abstract

Protease-activated receptor-2 (PAR-2) is one of a family of G-protein coupled transmembrane receptors activated by proteolytic release of a 'tethered' ligand. We previously reported this receptor has a pivotal role in chronic joint inflammation using a PAR-2 'knockout' mouse [1], but the serine protease responsible for its activation remains uncertain.

Original language	English
Pages	99-99
Number of pages	0
DOIs	https://doi.org/10.1186/ar1620
Publication status	Published - 17 Feb 2005
Event	25th European Workshop for Rheumatology Research - Glasgow, United Kingdom Duration: 24 Feb 2005 → 27 Feb 2005

Conference

Conference	25th European Workshop for Rheumatology Research
Country/Territory	United Kingdom
City	Glasgow
Period	24/02/05 → 27/02/05

Keywords

poster
joint inflammation
arthritis
physiology

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10.1186/ar1620

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abstract = "Protease-activated receptor-2 (PAR-2) is one of a family of G-protein coupled transmembrane receptors activated by proteolytic release of a 'tethered' ligand. We previously reported this receptor has a pivotal role in chronic joint inflammation using a PAR-2 'knockout' mouse [1], but the serine protease responsible for its activation remains uncertain.",

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AU - Kelso, E.B.

AU - Dunning, L.

AU - Lockhart, J.C.

AU - Ferrell, W.R.

AU - Plevin, R.

AU - Sommerhoff, C.P.

PY - 2005/2/17

Y1 - 2005/2/17

N2 - Protease-activated receptor-2 (PAR-2) is one of a family of G-protein coupled transmembrane receptors activated by proteolytic release of a 'tethered' ligand. We previously reported this receptor has a pivotal role in chronic joint inflammation using a PAR-2 'knockout' mouse [1], but the serine protease responsible for its activation remains uncertain.

AB - Protease-activated receptor-2 (PAR-2) is one of a family of G-protein coupled transmembrane receptors activated by proteolytic release of a 'tethered' ligand. We previously reported this receptor has a pivotal role in chronic joint inflammation using a PAR-2 'knockout' mouse [1], but the serine protease responsible for its activation remains uncertain.

KW - poster

KW - joint inflammation

KW - arthritis

KW - physiology

UR - http://dx.doi.org/10.1186/ar1620

U2 - 10.1186/ar1620

DO - 10.1186/ar1620

M3 - Poster

SP - 99

EP - 99

T2 - 25th European Workshop for Rheumatology Research

Y2 - 24 February 2005 through 27 February 2005

ER -

Tryptase as a PAR-2 activator in joint inflammation

Abstract

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