Tryptase as a PAR-2 activator in joint inflammation

E.B. Kelso, L. Dunning, J.C. Lockhart, W.R. Ferrell, R. Plevin, C.P. Sommerhoff

Research output: Contribution to conferencePoster

Abstract

Protease-activated receptor-2 (PAR-2) is one of a family of G-protein coupled transmembrane receptors activated by proteolytic release of a 'tethered' ligand. We previously reported this receptor has a pivotal role in chronic joint inflammation using a PAR-2 'knockout' mouse [1], but the serine protease responsible for its activation remains uncertain.
Original languageEnglish
Pages99-99
Number of pages0
DOIs
Publication statusPublished - 17 Feb 2005
Event25th European Workshop for Rheumatology Research - Glasgow, United Kingdom
Duration: 24 Feb 200527 Feb 2005

Conference

Conference25th European Workshop for Rheumatology Research
CountryUnited Kingdom
CityGlasgow
Period24/02/0527/02/05

Keywords

  • poster
  • joint inflammation
  • arthritis
  • physiology

Cite this