Tryptase as a PAR-2 activator in joint inflammation

E.B. Kelso, L. Dunning, J.C. Lockhart, W.R. Ferrell, R. Plevin, C.P. Sommerhoff

Research output: Contribution to conferencePoster

Abstract

Protease-activated receptor-2 (PAR-2) is one of a family of G-protein coupled transmembrane receptors activated by proteolytic release of a 'tethered' ligand. We previously reported this receptor has a pivotal role in chronic joint inflammation using a PAR-2 'knockout' mouse [1], but the serine protease responsible for its activation remains uncertain.
LanguageEnglish
Pages99-99
Number of pages0
DOIs
Publication statusPublished - 17 Feb 2005
Event25th European Workshop for Rheumatology Research - Glasgow, United Kingdom
Duration: 24 Feb 200527 Feb 2005

Conference

Conference25th European Workshop for Rheumatology Research
CountryUnited Kingdom
CityGlasgow
Period24/02/0527/02/05

Fingerprint

PAR-2 Receptor
Tryptases
Joints
Inflammation
Serine Proteases
G-Protein-Coupled Receptors
Knockout Mice
Ligands

Keywords

  • poster
  • joint inflammation
  • arthritis
  • physiology

Cite this

Kelso, E. B., Dunning, L., Lockhart, J. C., Ferrell, W. R., Plevin, R., & Sommerhoff, C. P. (2005). Tryptase as a PAR-2 activator in joint inflammation. 99-99. Poster session presented at 25th European Workshop for Rheumatology Research, Glasgow, United Kingdom. https://doi.org/10.1186/ar1620
Kelso, E.B. ; Dunning, L. ; Lockhart, J.C. ; Ferrell, W.R. ; Plevin, R. ; Sommerhoff, C.P. / Tryptase as a PAR-2 activator in joint inflammation. Poster session presented at 25th European Workshop for Rheumatology Research, Glasgow, United Kingdom.
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abstract = "Protease-activated receptor-2 (PAR-2) is one of a family of G-protein coupled transmembrane receptors activated by proteolytic release of a 'tethered' ligand. We previously reported this receptor has a pivotal role in chronic joint inflammation using a PAR-2 'knockout' mouse [1], but the serine protease responsible for its activation remains uncertain.",
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author = "E.B. Kelso and L. Dunning and J.C. Lockhart and W.R. Ferrell and R. Plevin and C.P. Sommerhoff",
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Kelso, EB, Dunning, L, Lockhart, JC, Ferrell, WR, Plevin, R & Sommerhoff, CP 2005, 'Tryptase as a PAR-2 activator in joint inflammation' 25th European Workshop for Rheumatology Research, Glasgow, United Kingdom, 24/02/05 - 27/02/05, pp. 99-99. https://doi.org/10.1186/ar1620

Tryptase as a PAR-2 activator in joint inflammation. / Kelso, E.B.; Dunning, L.; Lockhart, J.C.; Ferrell, W.R.; Plevin, R.; Sommerhoff, C.P.

2005. 99-99 Poster session presented at 25th European Workshop for Rheumatology Research, Glasgow, United Kingdom.

Research output: Contribution to conferencePoster

TY - CONF

T1 - Tryptase as a PAR-2 activator in joint inflammation

AU - Kelso, E.B.

AU - Dunning, L.

AU - Lockhart, J.C.

AU - Ferrell, W.R.

AU - Plevin, R.

AU - Sommerhoff, C.P.

PY - 2005/2/17

Y1 - 2005/2/17

N2 - Protease-activated receptor-2 (PAR-2) is one of a family of G-protein coupled transmembrane receptors activated by proteolytic release of a 'tethered' ligand. We previously reported this receptor has a pivotal role in chronic joint inflammation using a PAR-2 'knockout' mouse [1], but the serine protease responsible for its activation remains uncertain.

AB - Protease-activated receptor-2 (PAR-2) is one of a family of G-protein coupled transmembrane receptors activated by proteolytic release of a 'tethered' ligand. We previously reported this receptor has a pivotal role in chronic joint inflammation using a PAR-2 'knockout' mouse [1], but the serine protease responsible for its activation remains uncertain.

KW - poster

KW - joint inflammation

KW - arthritis

KW - physiology

UR - http://dx.doi.org/10.1186/ar1620

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DO - 10.1186/ar1620

M3 - Poster

SP - 99

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ER -

Kelso EB, Dunning L, Lockhart JC, Ferrell WR, Plevin R, Sommerhoff CP. Tryptase as a PAR-2 activator in joint inflammation. 2005. Poster session presented at 25th European Workshop for Rheumatology Research, Glasgow, United Kingdom. https://doi.org/10.1186/ar1620