Trivalent inactivated seasonal influenza vaccine effectiveness for the prevention of laboratory-confirmed influenza in a Scottish population 2000 to 2009

C R Simpson, N I Lone, K Kavanagh, L D Ritchie, C Robertson, Azziz Sheikh, J McMenamin

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To evaluate seasonal trivalent inactivated influenza vaccine effectiveness (VE) in Scotland, we performed a Scotland-wide linkage of patient-level primary care, hospital and virological swab data from 3,323 swabs (pooling data over nine influenza seasons: 2000/01 to 2008/09). We estimated the VE for reducing real-time RT-PCR-confirmed influenza using a test-negative study design. Vaccination was associated with a 57% (95% confidence interval (CI): 31–73) reduction in the risk of PCR-confirmed influenza. VE was 60% (95% CI: 22–79) for patients younger than 65 years and clinically at risk of serious complications from influenza, and 19% (95% CI: −104 to 68) for any individual 65 years and older. Vaccination was associated with substantial, sustained reductions in laboratory-confirmed influenza in the general population and younger patients in clinical at-risk groups.
Original languageEnglish
Article number2
Number of pages7
Issue number8
Publication statusPublished - 26 Feb 2015


  • influenza
  • secondary care
  • primary care
  • vaccine effectiveness
  • trivalent inactivated influenza vaccine
  • vaccines and immunization

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