Abstract
| Language | English |
|---|---|
| Title of host publication | Synthesis and applications of isotopically labelled compounds, volume 7 |
| Subtitle of host publication | proceedings of the 7th international symposium, Dresden 18-22 June 2000 |
| Editors | Ulrich Pleiss, R. Voges |
| Publisher | Wiley-Blackwell |
| Pages | 80-83 |
| Number of pages | 4 |
| ISBN (Print) | 0471495018 |
| Publication status | Published - 30 Jan 2001 |
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Keywords
- tritium labeling
- PXR ligand GW5801
- tritium exchange reaction
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Tritium labeling of the PXR ligand GW5801 - an unexpected tritium exchange reaction. / Chappelle, Michael R.; Morgan, Alan D.; Tomkinson, Nicholas C. O.; Willson, Timothy M.
Synthesis and applications of isotopically labelled compounds, volume 7: proceedings of the 7th international symposium, Dresden 18-22 June 2000. ed. / Ulrich Pleiss; R. Voges. Wiley-Blackwell, 2001. p. 80-83.Research output: Chapter in Book/Report/Conference proceeding › Other chapter contribution
TY - CHAP
T1 - Tritium labeling of the PXR ligand GW5801 - an unexpected tritium exchange reaction
AU - Chappelle, Michael R.
AU - Morgan, Alan D.
AU - Tomkinson, Nicholas C. O.
AU - Willson, Timothy M.
N1 - CAPLUS AN 2002:174743(Conference) 2nd ISBn print: 9780471495017
PY - 2001/1/30
Y1 - 2001/1/30
N2 - H-T exchange on 4,3,5-HO(Me3C)2C6H2CHO in presence of Crabtree's catalyst gave exclusively 4,3,5-HO(Me3C)2C6H2CTO, which was treated with CH2[P(O)(OEt)2]2 to give 4,3,5-HO(Me3C)2C6H2CT:CH[P(O)(OEt)2]2. The absence of ring tritiation in 4,3,5-HO(Me3C)2C6H2CHO is attributed to steric hindrance by the tert.-Bu groups. [on SciFinder(R)]
AB - H-T exchange on 4,3,5-HO(Me3C)2C6H2CHO in presence of Crabtree's catalyst gave exclusively 4,3,5-HO(Me3C)2C6H2CTO, which was treated with CH2[P(O)(OEt)2]2 to give 4,3,5-HO(Me3C)2C6H2CT:CH[P(O)(OEt)2]2. The absence of ring tritiation in 4,3,5-HO(Me3C)2C6H2CHO is attributed to steric hindrance by the tert.-Bu groups. [on SciFinder(R)]
KW - tritium labeling
KW - PXR ligand GW5801
KW - tritium exchange reaction
M3 - Other chapter contribution
SN - 0471495018
SP - 80
EP - 83
BT - Synthesis and applications of isotopically labelled compounds, volume 7
A2 - Pleiss, Ulrich
A2 - Voges, R.
PB - Wiley-Blackwell
ER -