Abstract
H-T exchange on 4,3,5-HO(Me3C)2C6H2CHO in presence of Crabtree's catalyst gave exclusively 4,3,5-HO(Me3C)2C6H2CTO, which was treated with CH2[P(O)(OEt)2]2 to give 4,3,5-HO(Me3C)2C6H2CT:CH[P(O)(OEt)2]2. The absence of ring tritiation in 4,3,5-HO(Me3C)2C6H2CHO is attributed to steric hindrance by the tert.-Bu groups. [on SciFinder(R)]
| Original language | English |
|---|---|
| Title of host publication | Synthesis and applications of isotopically labelled compounds, volume 7 |
| Subtitle of host publication | proceedings of the 7th international symposium, Dresden 18-22 June 2000 |
| Editors | Ulrich Pleiss, R. Voges |
| Publisher | Wiley-Blackwell |
| Pages | 80-83 |
| Number of pages | 4 |
| ISBN (Print) | 0471495018 |
| Publication status | Published - 30 Jan 2001 |
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Keywords
- tritium labeling
- PXR ligand GW5801
- tritium exchange reaction
Cite this
Chappelle, M. R., Morgan, A. D., Tomkinson, N. C. O., & Willson, T. M. (2001). Tritium labeling of the PXR ligand GW5801 - an unexpected tritium exchange reaction. In U. Pleiss, & R. Voges (Eds.), Synthesis and applications of isotopically labelled compounds, volume 7: proceedings of the 7th international symposium, Dresden 18-22 June 2000 (pp. 80-83). Wiley-Blackwell.