Abstract
H-T exchange on 4,3,5-HO(Me3C)2C6H2CHO in presence of Crabtree's catalyst gave exclusively 4,3,5-HO(Me3C)2C6H2CTO, which was treated with CH2[P(O)(OEt)2]2 to give 4,3,5-HO(Me3C)2C6H2CT:CH[P(O)(OEt)2]2. The absence of ring tritiation in 4,3,5-HO(Me3C)2C6H2CHO is attributed to steric hindrance by the tert.-Bu groups. [on SciFinder(R)]
Original language | English |
---|---|
Title of host publication | Synthesis and applications of isotopically labelled compounds, volume 7 |
Subtitle of host publication | proceedings of the 7th international symposium, Dresden 18-22 June 2000 |
Editors | Ulrich Pleiss, R. Voges |
Publisher | Wiley-Blackwell |
Pages | 80-83 |
Number of pages | 4 |
ISBN (Print) | 0471495018 |
Publication status | Published - 30 Jan 2001 |
Keywords
- tritium labeling
- PXR ligand GW5801
- tritium exchange reaction