Trends in colorectal cancer mortality in Europe: retrospective analysis of the WHO mortality database

Driss Ait Ouakrim, Cécile Pizot, Magali Boniol, Matteo Malvezzi, Mathieu Boniol, Eva Negri, Maria Bota, Mark A Jenkins, Harry Bleiberg, Philippe Autier

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Objective: To examine changes in colorectal cancermortality in 34 European countries between 1970 and 2011.

Design: Retrospective trend analysis.
Data source: World Health Organization mortality database.
Population: Deaths from colorectal cancer between 1970and 2011. Profound changes in screening and treatment efficiency took place after 1988; therefore, particular attention was paid to the evolution of colorectal cancer mortality in the subsequent period.
Main outcomes measures: Time trends in rates of colorectal cancer mortality, using joinpoint regression analysis. Rates were age adjusted using the standard European population. Results: From 1989 to 2011, colorectal cancer mortality increased by a median of 6.0% for men and decreased by a median of 14.7% for women in the 34 European countries. Reductions in colorectal cancer mortality of more than 25% in men and 30% in women occurred in Austria, Switzerland, Germany, the United Kingdom, Belgium, the Czech Republic, Luxembourg, and Ireland. By contrast, mortality rates fell by less than 17% in the Netherlands and Sweden for both sexes. Over the same period, smaller or no declines occurred in most central European countries. Substantial mortality increases occurred in Croatia, the former Yugoslav republic of Macedonia, and Romania for both sexes and in most eastern European countries for men. In countries with decreasing mortality, reductions were more important for women of all ages and men younger than 65 years. In the 27 European Union member states, colorectal cancer mortality fell by 13.0% in men and 27.0% in women, compared with corresponding reductions of 39.8% and 38.8% in the United States.
Conclusion: Over the past 40 years, there has been considerable disparity in the level of colorectal cancer mortality between European countries, as well as between men and women and age categories. Countries with the largest reductions in colorectal cancer mortality are characterised by better accessibility to screening services, especially endoscopic screening, and specialised care.
LanguageEnglish
Article numberh4970
Number of pages10
JournalBMJ
Volume351
DOIs
Publication statusPublished - 6 Oct 2015

Fingerprint

Colorectal Neoplasms
Databases
Mortality
Macedonia (Republic)
Luxembourg
Romania
Croatia
Austria
Information Storage and Retrieval
Czech Republic
Belgium
European Union
Switzerland
Ireland
Sweden
Netherlands
Population
Germany
Regression Analysis
Outcome Assessment (Health Care)

Keywords

  • cancer
  • mortality
  • analysis
  • Europe

Cite this

Ouakrim, Driss Ait ; Pizot, Cécile ; Boniol, Magali ; Malvezzi, Matteo ; Boniol, Mathieu ; Negri, Eva ; Bota, Maria ; Jenkins, Mark A ; Bleiberg, Harry ; Autier, Philippe. / Trends in colorectal cancer mortality in Europe : retrospective analysis of the WHO mortality database. In: BMJ. 2015 ; Vol. 351.
@article{38a73adb3dcf442ebddce72c16624b8f,
title = "Trends in colorectal cancer mortality in Europe: retrospective analysis of the WHO mortality database",
abstract = "Objective: To examine changes in colorectal cancermortality in 34 European countries between 1970 and 2011. Design: Retrospective trend analysis.Data source: World Health Organization mortality database. Population: Deaths from colorectal cancer between 1970and 2011. Profound changes in screening and treatment efficiency took place after 1988; therefore, particular attention was paid to the evolution of colorectal cancer mortality in the subsequent period.Main outcomes measures: Time trends in rates of colorectal cancer mortality, using joinpoint regression analysis. Rates were age adjusted using the standard European population. Results: From 1989 to 2011, colorectal cancer mortality increased by a median of 6.0{\%} for men and decreased by a median of 14.7{\%} for women in the 34 European countries. Reductions in colorectal cancer mortality of more than 25{\%} in men and 30{\%} in women occurred in Austria, Switzerland, Germany, the United Kingdom, Belgium, the Czech Republic, Luxembourg, and Ireland. By contrast, mortality rates fell by less than 17{\%} in the Netherlands and Sweden for both sexes. Over the same period, smaller or no declines occurred in most central European countries. Substantial mortality increases occurred in Croatia, the former Yugoslav republic of Macedonia, and Romania for both sexes and in most eastern European countries for men. In countries with decreasing mortality, reductions were more important for women of all ages and men younger than 65 years. In the 27 European Union member states, colorectal cancer mortality fell by 13.0{\%} in men and 27.0{\%} in women, compared with corresponding reductions of 39.8{\%} and 38.8{\%} in the United States. Conclusion: Over the past 40 years, there has been considerable disparity in the level of colorectal cancer mortality between European countries, as well as between men and women and age categories. Countries with the largest reductions in colorectal cancer mortality are characterised by better accessibility to screening services, especially endoscopic screening, and specialised care.",
keywords = "cancer, mortality, analysis, Europe",
author = "Ouakrim, {Driss Ait} and C{\'e}cile Pizot and Magali Boniol and Matteo Malvezzi and Mathieu Boniol and Eva Negri and Maria Bota and Jenkins, {Mark A} and Harry Bleiberg and Philippe Autier",
year = "2015",
month = "10",
day = "6",
doi = "10.1136/bmj.h4970",
language = "English",
volume = "351",
journal = "BMJ",
issn = "0959-8138",

}

Ouakrim, DA, Pizot, C, Boniol, M, Malvezzi, M, Boniol, M, Negri, E, Bota, M, Jenkins, MA, Bleiberg, H & Autier, P 2015, 'Trends in colorectal cancer mortality in Europe: retrospective analysis of the WHO mortality database' BMJ, vol. 351, h4970. https://doi.org/10.1136/bmj.h4970

Trends in colorectal cancer mortality in Europe : retrospective analysis of the WHO mortality database. / Ouakrim, Driss Ait; Pizot, Cécile; Boniol, Magali; Malvezzi, Matteo; Boniol, Mathieu; Negri, Eva; Bota, Maria; Jenkins, Mark A; Bleiberg, Harry; Autier, Philippe.

In: BMJ, Vol. 351, h4970, 06.10.2015.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Trends in colorectal cancer mortality in Europe

T2 - BMJ

AU - Ouakrim, Driss Ait

AU - Pizot, Cécile

AU - Boniol, Magali

AU - Malvezzi, Matteo

AU - Boniol, Mathieu

AU - Negri, Eva

AU - Bota, Maria

AU - Jenkins, Mark A

AU - Bleiberg, Harry

AU - Autier, Philippe

PY - 2015/10/6

Y1 - 2015/10/6

N2 - Objective: To examine changes in colorectal cancermortality in 34 European countries between 1970 and 2011. Design: Retrospective trend analysis.Data source: World Health Organization mortality database. Population: Deaths from colorectal cancer between 1970and 2011. Profound changes in screening and treatment efficiency took place after 1988; therefore, particular attention was paid to the evolution of colorectal cancer mortality in the subsequent period.Main outcomes measures: Time trends in rates of colorectal cancer mortality, using joinpoint regression analysis. Rates were age adjusted using the standard European population. Results: From 1989 to 2011, colorectal cancer mortality increased by a median of 6.0% for men and decreased by a median of 14.7% for women in the 34 European countries. Reductions in colorectal cancer mortality of more than 25% in men and 30% in women occurred in Austria, Switzerland, Germany, the United Kingdom, Belgium, the Czech Republic, Luxembourg, and Ireland. By contrast, mortality rates fell by less than 17% in the Netherlands and Sweden for both sexes. Over the same period, smaller or no declines occurred in most central European countries. Substantial mortality increases occurred in Croatia, the former Yugoslav republic of Macedonia, and Romania for both sexes and in most eastern European countries for men. In countries with decreasing mortality, reductions were more important for women of all ages and men younger than 65 years. In the 27 European Union member states, colorectal cancer mortality fell by 13.0% in men and 27.0% in women, compared with corresponding reductions of 39.8% and 38.8% in the United States. Conclusion: Over the past 40 years, there has been considerable disparity in the level of colorectal cancer mortality between European countries, as well as between men and women and age categories. Countries with the largest reductions in colorectal cancer mortality are characterised by better accessibility to screening services, especially endoscopic screening, and specialised care.

AB - Objective: To examine changes in colorectal cancermortality in 34 European countries between 1970 and 2011. Design: Retrospective trend analysis.Data source: World Health Organization mortality database. Population: Deaths from colorectal cancer between 1970and 2011. Profound changes in screening and treatment efficiency took place after 1988; therefore, particular attention was paid to the evolution of colorectal cancer mortality in the subsequent period.Main outcomes measures: Time trends in rates of colorectal cancer mortality, using joinpoint regression analysis. Rates were age adjusted using the standard European population. Results: From 1989 to 2011, colorectal cancer mortality increased by a median of 6.0% for men and decreased by a median of 14.7% for women in the 34 European countries. Reductions in colorectal cancer mortality of more than 25% in men and 30% in women occurred in Austria, Switzerland, Germany, the United Kingdom, Belgium, the Czech Republic, Luxembourg, and Ireland. By contrast, mortality rates fell by less than 17% in the Netherlands and Sweden for both sexes. Over the same period, smaller or no declines occurred in most central European countries. Substantial mortality increases occurred in Croatia, the former Yugoslav republic of Macedonia, and Romania for both sexes and in most eastern European countries for men. In countries with decreasing mortality, reductions were more important for women of all ages and men younger than 65 years. In the 27 European Union member states, colorectal cancer mortality fell by 13.0% in men and 27.0% in women, compared with corresponding reductions of 39.8% and 38.8% in the United States. Conclusion: Over the past 40 years, there has been considerable disparity in the level of colorectal cancer mortality between European countries, as well as between men and women and age categories. Countries with the largest reductions in colorectal cancer mortality are characterised by better accessibility to screening services, especially endoscopic screening, and specialised care.

KW - cancer

KW - mortality

KW - analysis

KW - Europe

UR - http://www.scopus.com/inward/record.url?scp=84947460407&partnerID=8YFLogxK

UR - http://www.bmj.com/thebmj

U2 - 10.1136/bmj.h4970

DO - 10.1136/bmj.h4970

M3 - Article

VL - 351

JO - BMJ

JF - BMJ

SN - 0959-8138

M1 - h4970

ER -

Ouakrim DA, Pizot C, Boniol M, Malvezzi M, Boniol M, Negri E et al. Trends in colorectal cancer mortality in Europe: retrospective analysis of the WHO mortality database. BMJ. 2015 Oct 6;351. h4970. https://doi.org/10.1136/bmj.h4970