990 poster Treatment of Patients with paediatric Ewing sarcoma (EWS). A single institutional experience

J.A. Nixon, I. Fragkandrea-Nixon, V. Sidi, D. Koliouskas

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Purpose: Ewing sarcoma (EWS) is a rare, non differentiated, high grademalignant bone tumor. It belongs to the neuroectodermal tumor group, thatconstitute a heterogeneous group of bone and soft tissue tumors. The aimof this study is to assess the clinical outcome of patients with EWS treatedwith the European Intergroup Cooperative Ewing Sarcoma Study (EICESS-92 and EURO EWING -99 ) protocols at a single center, during the period1994-2009.Materials: We included 19 pediatric patients with average age of 10,5 ( from3 to 15) years, 12 male ( 63%) and 7 female ( 33%) who were treated ac-cording to the protocols EICESS -92 (11 patients) and EURO EWING 99( 8). In order to diagnose EWS for each child, demographic data, clinicallaboratory, imaging findings (CT or MRI of the primary site, thorax CT forlung metastases, Tc -99m bone scan for bone metastases) and bone mar-row aspiration were evaluated. At the time of diagnosis, localized tumor wasobserved in 14 patients (73,6%), and metastatic disease in 5 patients (26,3%) (only lungs 2 ,combined or other sites 3). The most affected sites werefemur (7 patients 36,8%), distal lower extremity (6 patients 31,5%), pelvis(4 patients 21,04%) and rib (2 10,5%).The treatment plan included intensiveinduction chemotherapy (EICESS -92 for 11 and EURO EWING 99 for 8 pa-tients) consist of courses chemotherapy (Vincristine,Adriamicyn, Ifosfamideand Etoposide), surgery, radiotherapy and finally consolidation with 8 coursesIVA (Ifosfamide,Vincristine, Dactinomycin).Results: 12/19 patients are alive at 8,8 ( range 2 -15 ) years and 7 /19 diedfrom progressive disease(metastases or relapse). The 5 year overall survival(OS) was 63% and the 5 years eventfree survival (EFS) was 61,4%.Conclusions: Results indicate that OS and EFS of children with Ewing sar-coma is in accordance with current international bibliographic data. ImprovedEFS requires aggressive systemic chemotherapy, radiotherapy and surgery.
Original languageEnglish
Article numberS373
Number of pages1
JournalRadiotherapy and Oncology
Issue number1
Publication statusPublished - 1 May 2011


  • 990 poster
  • patients
  • paediatric ewing sarcoma (EWS)
  • single institution experience


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