Translational aspects of sphingosine 1-phosphate biology

Research output: Contribution to journalLiterature review

50 Citations (Scopus)

Abstract

Sphingosine 1-phosphate (S1P) is a bioactive lipid that has both physiological and pathophysiological roles. It regulates cellular processes such as proliferation, migration, survival and differentiation and affects all organ systems. S1P not only activates S1P-specific receptors to initiate cellular signalling pathways but also directly regulates specific intracellular target proteins. The therapeutic opportunities surrounding S1P signalling are numerous and exemplified by the recent approval of FTY720 (a sphingosine analogue, Gilenya™) for the treatment of relapsing multiple sclerosis. A major focus of research is to develop small-molecule antagonists/agonists/inhibitors that are specific to the different S1P receptor subtypes and the enzymes that regulate S1P levels. This review describes fundamental aspects of S1P biology with an emphasis on the translational potential of intervention therapeutics.
LanguageEnglish
Pages463-472
JournalTrends in Molecular Medicine
Volume17
Early online date21 Apr 2011
DOIs
Publication statusPublished - 2011

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Lysosphingolipid Receptors
Sphingosine
Multiple Sclerosis
sphingosine 1-phosphate
Lipids
Enzymes
Therapeutics
Research
Proteins
Fingolimod Hydrochloride

Keywords

  • intervention therapeutics
  • S1P
  • Sphingosine 1-phosphate
  • bioactive lipid

Cite this

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Translational aspects of sphingosine 1-phosphate biology. / Pyne, Susan; Pyne, Nigel J.

In: Trends in Molecular Medicine, Vol. 17, 2011, p. 463-472.

Research output: Contribution to journalLiterature review

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