Translation of an experimental oral vaccine formulation into a commercial product

Research output: Contribution to journalArticle

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Abstract

An effective experimental vaccine may fail to become a therapeutic reality for a number of scientific, regulatory or commercial reasons. In this review, we share some of our personal experiences as University-based researchers and provide an account of some of the problems that we have encountered during preliminary scale-up and assessment of an oral influenza vaccine formulation. Many of the problems we have faced have been non-scientific and related to identifying project-funding sources, finding suitable contract manufacturing companies that are GMP compliant, and protecting intellectual property generated from the scientific studies. The review is intended as a practical guide that will allow other researchers to adopt effective strategies to permit the translation of an effective experimental formulation to a viable commercial product.

Original languageEnglish
Pages (from-to)65-68
Number of pages4
JournalMethods
Volume38
Issue number2
DOIs
Publication statusPublished - 2006

Keywords

  • vaccines
  • manufacturing process
  • antibodies
  • quality control
  • commercial

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