Transition metal-mediated synthesis of oxazoles

Stefano Bresciani; Nicholas C. O. Tomkinson

doi:10.3987/REV-14-808

Transition metal-mediated synthesis of oxazoles

Stefano Bresciani, Nicholas C. O. Tomkinson

Pure And Applied Chemistry

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Abstract

Among the synthetic methods for the formation of the oxazole ring, transition metal-mediated protocols are the most attractive in terms of selectivity, efficiency and mildness of reaction conditions. In this review we discuss methods for the preparation of oxazoles using transition metal complexes highlighting the key bonds being formed. This reveals critical gaps in the existing literature for the construction of this biologically significant ring system highlighting exciting opportunities for further research.

Original language	English
Pages (from-to)	2479-2543
Number of pages	65
Journal	Heterocycles
Volume	89
Issue number	11
DOIs	https://doi.org/10.3987/REV-14-808
Publication status	Published - 30 Oct 2014

Keywords

oxazole ring
reaction conditions
metal complexes

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10.3987/REV-14-808

Bresciani-Tomkinson-Heterocycles-2014-Transition-metal-mediated-synthesisAccepted author manuscript, 6.14 MBLicence: CC BY-NC-ND 4.0

Cite this

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AB - Among the synthetic methods for the formation of the oxazole ring, transition metal-mediated protocols are the most attractive in terms of selectivity, efficiency and mildness of reaction conditions. In this review we discuss methods for the preparation of oxazoles using transition metal complexes highlighting the key bonds being formed. This reveals critical gaps in the existing literature for the construction of this biologically significant ring system highlighting exciting opportunities for further research.

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KW - reaction conditions

KW - metal complexes

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Transition metal-mediated synthesis of oxazoles

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INNOVATIVE TARGETS FOR CIRCADIAN DRUG DISCOVERY: REV-ERBALPHA AND RORALPHA

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Transition metal-mediated synthesis of oxazoles

Abstract

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INNOVATIVE TARGETS FOR CIRCADIAN DRUG DISCOVERY: REV-ERBALPHA AND RORALPHA

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